The nuts and bolts of the platelet release reaction
Secretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstra...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-02-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2016.1240768 |
| _version_ | 1797684365115785216 |
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| author | Smita Joshi Sidney W. Whiteheart |
| author_facet | Smita Joshi Sidney W. Whiteheart |
| author_sort | Smita Joshi |
| collection | DOAJ |
| description | Secretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstrate that granule cargo release is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins, which are required for granule-plasma membrane fusion. Several SNARE regulators, which control when, where, and how the SNAREs interact, have been identified in platelets. Additionally, platelet SNAREs are controlled by post-translational modifications, e.g., phosphorylation and acylation. Although there have been many recent insights into the mechanisms of platelet secretion, many questions remain: have we identified all the important regulators, does calcium directly control the process, and is platelet secretion polarized. In this review, we focus on the mechanics of platelet secretion and discuss how the secretory machinery functions in the pathway leading to membrane fusion and cargo release. |
| first_indexed | 2024-03-12T00:28:38Z |
| format | Article |
| id | doaj.art-e151c20948dc4795aa78f38b5ae5bfd2 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:28:38Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-e151c20948dc4795aa78f38b5ae5bfd22023-09-15T10:26:29ZengTaylor & Francis GroupPlatelets0953-71041369-16352017-02-0128212913710.1080/09537104.2016.12407681240768The nuts and bolts of the platelet release reactionSmita Joshi0Sidney W. Whiteheart1University of KentuckyUniversity of KentuckySecretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstrate that granule cargo release is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins, which are required for granule-plasma membrane fusion. Several SNARE regulators, which control when, where, and how the SNAREs interact, have been identified in platelets. Additionally, platelet SNAREs are controlled by post-translational modifications, e.g., phosphorylation and acylation. Although there have been many recent insights into the mechanisms of platelet secretion, many questions remain: have we identified all the important regulators, does calcium directly control the process, and is platelet secretion polarized. In this review, we focus on the mechanics of platelet secretion and discuss how the secretory machinery functions in the pathway leading to membrane fusion and cargo release.http://dx.doi.org/10.1080/09537104.2016.1240768exocytosismunc13munc18rabsnaresstxbp5 |
| spellingShingle | Smita Joshi Sidney W. Whiteheart The nuts and bolts of the platelet release reaction Platelets exocytosis munc13 munc18 rab snares stxbp5 |
| title | The nuts and bolts of the platelet release reaction |
| title_full | The nuts and bolts of the platelet release reaction |
| title_fullStr | The nuts and bolts of the platelet release reaction |
| title_full_unstemmed | The nuts and bolts of the platelet release reaction |
| title_short | The nuts and bolts of the platelet release reaction |
| title_sort | nuts and bolts of the platelet release reaction |
| topic | exocytosis munc13 munc18 rab snares stxbp5 |
| url | http://dx.doi.org/10.1080/09537104.2016.1240768 |
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