Statins in Healthy Adults: A Meta-Analysis
<i>Background and Objectives</i>: In this paper, we investigated the efficacy of statin therapy on cardiovascular disease (CVD) reduction in adults with no known underlying health conditions by undertaking a meta-analysis and systematic review of the current evidence. <i>Materials...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/57/6/585 |
| _version_ | 1797531043305095168 |
|---|---|
| author | Lee Sandwith Patrice Forget |
| author_facet | Lee Sandwith Patrice Forget |
| author_sort | Lee Sandwith |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: In this paper, we investigated the efficacy of statin therapy on cardiovascular disease (CVD) reduction in adults with no known underlying health conditions by undertaking a meta-analysis and systematic review of the current evidence. <i>Materials and Methods</i>: We performed a systematic search to identify Primary Prevention Randomized Controlled Trials (RCTs) that compared statins with a control group where CVD events or mortality were the primary end point. Identified RCTs were evaluated and classified into categories depending on relevance in order to determine which type of meta-analysis would be feasible. <i>Results</i>: No differences were observed between categories with the exception of relative risk for all CVD events combined which showed a 12% statistically significant difference favouring studies which were known to include participants without underlying health conditions. Strong negative correlations between number-need-to-treat (NNT) and LDL-C reduction were observed for all Coronary Heart Disease (CHD) outcomes combined and all CVD outcomes combined. <i>Conclusions</i>: This project highlights the need for further research on the effects of statins on participants who do not suffer from underlying health conditions, given that no such studies have been conducted. |
| first_indexed | 2024-03-10T10:38:31Z |
| format | Article |
| id | doaj.art-e1534973a7234ae0a8704d667e2fcc7e |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T10:38:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e1534973a7234ae0a8704d667e2fcc7e2023-11-21T23:09:19ZengMDPI AGMedicina1010-660X1648-91442021-06-0157658510.3390/medicina57060585Statins in Healthy Adults: A Meta-AnalysisLee Sandwith0Patrice Forget1Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, Epidemiology Group, University of Aberdeen, Aberdeen AB25 2ZD, UKInstitute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, Epidemiology Group, University of Aberdeen, Aberdeen AB25 2ZD, UK<i>Background and Objectives</i>: In this paper, we investigated the efficacy of statin therapy on cardiovascular disease (CVD) reduction in adults with no known underlying health conditions by undertaking a meta-analysis and systematic review of the current evidence. <i>Materials and Methods</i>: We performed a systematic search to identify Primary Prevention Randomized Controlled Trials (RCTs) that compared statins with a control group where CVD events or mortality were the primary end point. Identified RCTs were evaluated and classified into categories depending on relevance in order to determine which type of meta-analysis would be feasible. <i>Results</i>: No differences were observed between categories with the exception of relative risk for all CVD events combined which showed a 12% statistically significant difference favouring studies which were known to include participants without underlying health conditions. Strong negative correlations between number-need-to-treat (NNT) and LDL-C reduction were observed for all Coronary Heart Disease (CHD) outcomes combined and all CVD outcomes combined. <i>Conclusions</i>: This project highlights the need for further research on the effects of statins on participants who do not suffer from underlying health conditions, given that no such studies have been conducted.https://www.mdpi.com/1648-9144/57/6/585statinscardiovascular disease and mortalitycholesterolprimary prevention |
| spellingShingle | Lee Sandwith Patrice Forget Statins in Healthy Adults: A Meta-Analysis Medicina statins cardiovascular disease and mortality cholesterol primary prevention |
| title | Statins in Healthy Adults: A Meta-Analysis |
| title_full | Statins in Healthy Adults: A Meta-Analysis |
| title_fullStr | Statins in Healthy Adults: A Meta-Analysis |
| title_full_unstemmed | Statins in Healthy Adults: A Meta-Analysis |
| title_short | Statins in Healthy Adults: A Meta-Analysis |
| title_sort | statins in healthy adults a meta analysis |
| topic | statins cardiovascular disease and mortality cholesterol primary prevention |
| url | https://www.mdpi.com/1648-9144/57/6/585 |
| work_keys_str_mv | AT leesandwith statinsinhealthyadultsametaanalysis AT patriceforget statinsinhealthyadultsametaanalysis |