Fibroblasts as Turned Agents in Cancer Progression
Differentiated epithelial cells reside in the homeostatic microenvironment of the native organ stroma. The stroma supports their normal function, their G<sub>0</sub> differentiated state, and their expansion/contraction through the various stages of the life cycle and physiologic functio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/7/2014 |
| _version_ | 1797608287460392960 |
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| author | Robert Wieder |
| author_facet | Robert Wieder |
| author_sort | Robert Wieder |
| collection | DOAJ |
| description | Differentiated epithelial cells reside in the homeostatic microenvironment of the native organ stroma. The stroma supports their normal function, their G<sub>0</sub> differentiated state, and their expansion/contraction through the various stages of the life cycle and physiologic functions of the host. When malignant transformation begins, the microenvironment tries to suppress and eliminate the transformed cells, while cancer cells, in turn, try to resist these suppressive efforts. The tumor microenvironment encompasses a large variety of cell types recruited by the tumor to perform different functions, among which fibroblasts are the most abundant. The dynamics of the mutual relationship change as the sides undertake an epic battle for control of the other. In the process, the cancer “wounds” the microenvironment through a variety of mechanisms and attracts distant mesenchymal stem cells to change their function from one attempting to suppress the cancer, to one that supports its growth, survival, and metastasis. Analogous reciprocal interactions occur as well between disseminated cancer cells and the metastatic microenvironment, where the microenvironment attempts to eliminate cancer cells or suppress their proliferation. However, the altered microenvironmental cells acquire novel characteristics that support malignant progression. Investigations have attempted to use these traits as targets of novel therapeutic approaches. |
| first_indexed | 2024-03-11T05:41:22Z |
| format | Article |
| id | doaj.art-e153725cff4c4066868d622bd792af13 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:41:22Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e153725cff4c4066868d622bd792af132023-11-17T16:24:52ZengMDPI AGCancers2072-66942023-03-01157201410.3390/cancers15072014Fibroblasts as Turned Agents in Cancer ProgressionRobert Wieder0Rutgers New Jersey Medical School and the Cancer Institute of New Jersey, Newark, NJ 07103, USADifferentiated epithelial cells reside in the homeostatic microenvironment of the native organ stroma. The stroma supports their normal function, their G<sub>0</sub> differentiated state, and their expansion/contraction through the various stages of the life cycle and physiologic functions of the host. When malignant transformation begins, the microenvironment tries to suppress and eliminate the transformed cells, while cancer cells, in turn, try to resist these suppressive efforts. The tumor microenvironment encompasses a large variety of cell types recruited by the tumor to perform different functions, among which fibroblasts are the most abundant. The dynamics of the mutual relationship change as the sides undertake an epic battle for control of the other. In the process, the cancer “wounds” the microenvironment through a variety of mechanisms and attracts distant mesenchymal stem cells to change their function from one attempting to suppress the cancer, to one that supports its growth, survival, and metastasis. Analogous reciprocal interactions occur as well between disseminated cancer cells and the metastatic microenvironment, where the microenvironment attempts to eliminate cancer cells or suppress their proliferation. However, the altered microenvironmental cells acquire novel characteristics that support malignant progression. Investigations have attempted to use these traits as targets of novel therapeutic approaches.https://www.mdpi.com/2072-6694/15/7/2014transformationtumor stromamicroenvironmentheterogeneitycancer-associated fibroblaststherapeutic targets |
| spellingShingle | Robert Wieder Fibroblasts as Turned Agents in Cancer Progression Cancers transformation tumor stroma microenvironment heterogeneity cancer-associated fibroblasts therapeutic targets |
| title | Fibroblasts as Turned Agents in Cancer Progression |
| title_full | Fibroblasts as Turned Agents in Cancer Progression |
| title_fullStr | Fibroblasts as Turned Agents in Cancer Progression |
| title_full_unstemmed | Fibroblasts as Turned Agents in Cancer Progression |
| title_short | Fibroblasts as Turned Agents in Cancer Progression |
| title_sort | fibroblasts as turned agents in cancer progression |
| topic | transformation tumor stroma microenvironment heterogeneity cancer-associated fibroblasts therapeutic targets |
| url | https://www.mdpi.com/2072-6694/15/7/2014 |
| work_keys_str_mv | AT robertwieder fibroblastsasturnedagentsincancerprogression |