Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome
Intrinsic and extrinsic aging affect the health of human skin. Extracellular matrix protein degradation, DNA damage and oxidative stress are known to disturb skin architecture and skin homeostasis leading to skin aging. Traditional Chinese Medicine (TCM) delivers a large amount of knowledge regardin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024021625 |
| _version_ | 1827316569770819584 |
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| author | Chunbo Feng Catherine Serre Weimiao Chen Isabelle Imbert Le Zhu Feng Ling |
| author_facet | Chunbo Feng Catherine Serre Weimiao Chen Isabelle Imbert Le Zhu Feng Ling |
| author_sort | Chunbo Feng |
| collection | DOAJ |
| description | Intrinsic and extrinsic aging affect the health of human skin. Extracellular matrix protein degradation, DNA damage and oxidative stress are known to disturb skin architecture and skin homeostasis leading to skin aging. Traditional Chinese Medicine (TCM) delivers a large amount of knowledge regarding the phytotherapeutic power of diverse plants. Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans are five plants used in TCM for their protective effect. In this study, several combinations of these TCM plants were explored: first, an in silico analysis was performed to predict their potential to target biological activities in the skin and then, some predictions were verified with in vitro studies to underline the synergistic effect of plant extracts. The results showed a stronger anti-aging activity for the combination with the five plants compared to the combination with Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum and, compared to Panax ginseng alone. |
| first_indexed | 2024-03-07T15:46:57Z |
| format | Article |
| id | doaj.art-e1545d2a25eb45049683f460d029bfca |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:16:44Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e1545d2a25eb45049683f460d029bfca2024-03-17T07:55:11ZengElsevierHeliyon2405-84402024-03-01105e26131Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcomeChunbo Feng0Catherine Serre1Weimiao Chen2Isabelle Imbert3Le Zhu4Feng Ling5R&D Center, Shanghai Jahwa United Co., Ltd., China; Corresponding author.Biofunctionals & Naturals, Ashland Specialties France, Sophia Antipolis 06410, FranceR&D Center, Shanghai Jahwa United Co., Ltd., ChinaBiofunctionals & Naturals, Ashland Specialties France, Sophia Antipolis 06410, FranceR&D Center, Shanghai Jahwa United Co., Ltd., ChinaBiofunctionals & Naturals, Ashland Specialties France, Sophia Antipolis 06410, FranceIntrinsic and extrinsic aging affect the health of human skin. Extracellular matrix protein degradation, DNA damage and oxidative stress are known to disturb skin architecture and skin homeostasis leading to skin aging. Traditional Chinese Medicine (TCM) delivers a large amount of knowledge regarding the phytotherapeutic power of diverse plants. Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans are five plants used in TCM for their protective effect. In this study, several combinations of these TCM plants were explored: first, an in silico analysis was performed to predict their potential to target biological activities in the skin and then, some predictions were verified with in vitro studies to underline the synergistic effect of plant extracts. The results showed a stronger anti-aging activity for the combination with the five plants compared to the combination with Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum and, compared to Panax ginseng alone.http://www.sciencedirect.com/science/article/pii/S2405844024021625PhytochemicalsPlant extract combinationIn silico analysisskin anti-aging |
| spellingShingle | Chunbo Feng Catherine Serre Weimiao Chen Isabelle Imbert Le Zhu Feng Ling Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome Heliyon Phytochemicals Plant extract combination In silico analysis skin anti-aging |
| title | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| title_full | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| title_fullStr | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| title_full_unstemmed | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| title_short | Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome |
| title_sort | synergistic effect of panax ginseng polygonatum cyrtonema epiphyllum oxypetalum nelumbo nucifera and osmanthus fragrans extracts on skin aging regulation from in silico predictions to in vitro outcome |
| topic | Phytochemicals Plant extract combination In silico analysis skin anti-aging |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024021625 |
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