Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals
<p class="p1"><span class="s1"><em>Genetic and epigenetic mechanisms of spermatogenesis – long process with many stages regulation are discussed. DNA code is the entirety of hereditary information, epigenetic mechanisms of gene regulation act without altering pr...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-04-01
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| Series: | Андрология и генитальная хирургия |
| Subjects: | |
| Online Access: | http://agx.abvpress.ru/index.php/jour/article/view/128 |
| _version_ | 1798004760455938048 |
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| author | L. F. Kurilo M. I. Shtaut |
| author_facet | L. F. Kurilo M. I. Shtaut |
| author_sort | L. F. Kurilo |
| collection | DOAJ |
| description | <p class="p1"><span class="s1"><em>Genetic and epigenetic mechanisms of spermatogenesis – long process with many stages regulation are discussed. DNA code is the entirety of hereditary information, epigenetic mechanisms of gene regulation act without altering primary nucleotide sequences. Epigenetic regulation is a complex process, in which components of different groups of epigenetic modifications (non-coding RNAs, DNA methylation and histone modification) work together. Mistakes in any of the components of the process may cause impaired spermatogenesis and/or infertility, and may cause epigenetic diseases. </em></span></p><p class="p1"><span class="s1"><em>Nowadays 90 imprinted genes and loci on 13 chromosomes are revealed. More then 10 human diseases involving genomic imprinting are known (Angelman syndrome, Prader–Willi syndrome, Russell–Silver syndrome, Beckwith–Wiedemann syndrome etc.). DNA methylation is essential for normal development and is associated with a number of key processes including animal growth and development, transcription, DNA replication and reparation, cell differentiation, genomic imprinting, X-chromosome inactivation, suppression of repetitive elements and carcinogenesis. </em></span></p> |
| first_indexed | 2024-04-11T12:29:35Z |
| format | Article |
| id | doaj.art-e154a075273b4642a60204898d8ca472 |
| institution | Directory Open Access Journal |
| issn | 2070-9781 |
| language | Russian |
| last_indexed | 2024-04-11T12:29:35Z |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Андрология и генитальная хирургия |
| spelling | doaj.art-e154a075273b4642a60204898d8ca4722022-12-22T04:23:50ZrusABV-pressАндрология и генитальная хирургия2070-97812015-04-011613140122Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammalsL. F. Kurilo0M. I. Shtaut1Laboratory of Genetics of Violations of Reproduction, Medical and Genetic Research Center; 1 Moskvorechiye St., Moscow, 115478, RussiaLaboratory of Genetics of Violations of Reproduction, Medical and Genetic Research Center; 1 Moskvorechiye St., Moscow, 115478, Russia<p class="p1"><span class="s1"><em>Genetic and epigenetic mechanisms of spermatogenesis – long process with many stages regulation are discussed. DNA code is the entirety of hereditary information, epigenetic mechanisms of gene regulation act without altering primary nucleotide sequences. Epigenetic regulation is a complex process, in which components of different groups of epigenetic modifications (non-coding RNAs, DNA methylation and histone modification) work together. Mistakes in any of the components of the process may cause impaired spermatogenesis and/or infertility, and may cause epigenetic diseases. </em></span></p><p class="p1"><span class="s1"><em>Nowadays 90 imprinted genes and loci on 13 chromosomes are revealed. More then 10 human diseases involving genomic imprinting are known (Angelman syndrome, Prader–Willi syndrome, Russell–Silver syndrome, Beckwith–Wiedemann syndrome etc.). DNA methylation is essential for normal development and is associated with a number of key processes including animal growth and development, transcription, DNA replication and reparation, cell differentiation, genomic imprinting, X-chromosome inactivation, suppression of repetitive elements and carcinogenesis. </em></span></p>http://agx.abvpress.ru/index.php/jour/article/view/128geneticsepigeneticsspermatogenesisDNA methylationhistone modificationschromosomeschromatinprochromosomesmitosismeiosis |
| spellingShingle | L. F. Kurilo M. I. Shtaut Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals Андрология и генитальная хирургия genetics epigenetics spermatogenesis DNA methylation histone modifications chromosomes chromatin prochromosomes mitosis meiosis |
| title | Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals |
| title_full | Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals |
| title_fullStr | Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals |
| title_full_unstemmed | Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals |
| title_short | Genetic and epigenetic mechanisms of regulation, chronology and dynamics of spermatogenesis of mammals |
| title_sort | genetic and epigenetic mechanisms of regulation chronology and dynamics of spermatogenesis of mammals |
| topic | genetics epigenetics spermatogenesis DNA methylation histone modifications chromosomes chromatin prochromosomes mitosis meiosis |
| url | http://agx.abvpress.ru/index.php/jour/article/view/128 |
| work_keys_str_mv | AT lfkurilo geneticandepigeneticmechanismsofregulationchronologyanddynamicsofspermatogenesisofmammals AT mishtaut geneticandepigeneticmechanismsofregulationchronologyanddynamicsofspermatogenesisofmammals |