Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes
Cancer is a serious problem in modern medicine, mainly due to the insufficient effectiveness of currently available therapies. There is a particular interest in compounds of natural origin, which can be used in the prophylaxis, as well as in the treatment and support of cancer treatment. One such co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2901 |
| _version_ | 1797534202948747264 |
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| author | Iwona Jarocka-Karpowicz Agnieszka Markowska |
| author_facet | Iwona Jarocka-Karpowicz Agnieszka Markowska |
| author_sort | Iwona Jarocka-Karpowicz |
| collection | DOAJ |
| description | Cancer is a serious problem in modern medicine, mainly due to the insufficient effectiveness of currently available therapies. There is a particular interest in compounds of natural origin, which can be used in the prophylaxis, as well as in the treatment and support of cancer treatment. One such compound is jasmonic acid (3-oxo-2-(pent-2’-enyl)cyclopentane acetic acid; isolated active form: <i>trans</i>-(-)-(3<i>R</i>,7<i>R</i>)- and <i>cis</i>-(+)-(3<i>R</i>,7<i>S</i>)-jasmonic acid) and its derivatives, which, due to their wide range of biological activities, are also proposed as potential therapeutic agents. Therefore, a review of literature data on the biological activity of jasmonates was prepared, with particular emphasis on the mechanisms of jasmonate action in neoplastic diseases. The anti-tumor activity of jasmonate compounds is based on altered cellular ATP levels; induction of re-differentiation through the action of Mitogen Activated Protein Kinases (MAPKs); the induction of the apoptosis by reactive oxygen species. Jasmonates can be used in anti-cancer therapy in combination with other known drugs, such as cisplatin, paclitaxel or doxorubicin, showing a synergistic effect. The structure–activity relationship of novel jasmonate derivatives with anti-tumor, anti-inflammatory and anti-aging effects is also shown. |
| first_indexed | 2024-03-10T11:27:17Z |
| format | Article |
| id | doaj.art-e154e062c82441938bd14d2818571862 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:27:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e154e062c82441938bd14d28185718622023-11-21T19:37:28ZengMDPI AGMolecules1420-30492021-05-012610290110.3390/molecules26102901Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic ProcessesIwona Jarocka-Karpowicz0Agnieszka Markowska1Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandDepartment of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222 Bialystok, PolandCancer is a serious problem in modern medicine, mainly due to the insufficient effectiveness of currently available therapies. There is a particular interest in compounds of natural origin, which can be used in the prophylaxis, as well as in the treatment and support of cancer treatment. One such compound is jasmonic acid (3-oxo-2-(pent-2’-enyl)cyclopentane acetic acid; isolated active form: <i>trans</i>-(-)-(3<i>R</i>,7<i>R</i>)- and <i>cis</i>-(+)-(3<i>R</i>,7<i>S</i>)-jasmonic acid) and its derivatives, which, due to their wide range of biological activities, are also proposed as potential therapeutic agents. Therefore, a review of literature data on the biological activity of jasmonates was prepared, with particular emphasis on the mechanisms of jasmonate action in neoplastic diseases. The anti-tumor activity of jasmonate compounds is based on altered cellular ATP levels; induction of re-differentiation through the action of Mitogen Activated Protein Kinases (MAPKs); the induction of the apoptosis by reactive oxygen species. Jasmonates can be used in anti-cancer therapy in combination with other known drugs, such as cisplatin, paclitaxel or doxorubicin, showing a synergistic effect. The structure–activity relationship of novel jasmonate derivatives with anti-tumor, anti-inflammatory and anti-aging effects is also shown.https://www.mdpi.com/1420-3049/26/10/2901jasmonic acidanti-cancer drugsstructure–activity relationshipnovel drug |
| spellingShingle | Iwona Jarocka-Karpowicz Agnieszka Markowska Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes Molecules jasmonic acid anti-cancer drugs structure–activity relationship novel drug |
| title | Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes |
| title_full | Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes |
| title_fullStr | Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes |
| title_full_unstemmed | Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes |
| title_short | Jasmonate Compounds and Their Derivatives in the Regulation of the Neoplastic Processes |
| title_sort | jasmonate compounds and their derivatives in the regulation of the neoplastic processes |
| topic | jasmonic acid anti-cancer drugs structure–activity relationship novel drug |
| url | https://www.mdpi.com/1420-3049/26/10/2901 |
| work_keys_str_mv | AT iwonajarockakarpowicz jasmonatecompoundsandtheirderivativesintheregulationoftheneoplasticprocesses AT agnieszkamarkowska jasmonatecompoundsandtheirderivativesintheregulationoftheneoplasticprocesses |