Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia?
The International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, clinical and public health research relating to animal and human papillomaviruses. This editorial is a personal reflection, it does not attempt to be comprehensive and reports on s...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Tumour Virus Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666679023000101 |
| _version_ | 1827578507974148096 |
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| author | Peter L. Stern |
| author_facet | Peter L. Stern |
| author_sort | Peter L. Stern |
| collection | DOAJ |
| description | The International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, clinical and public health research relating to animal and human papillomaviruses. This editorial is a personal reflection, it does not attempt to be comprehensive and reports on some key aspects centred on the prospects for immune interventions in prevention and treatment of HPV infections and early precancers with a focus on cervical neoplasia. There is optimism for the future impact of immunotherapy in treating early HPV associated disease. This will depend on developing an appropriate design of vaccines and delivery vehicles which then need to be properly tested in clinical trials that are able to measure a useful clinical endpoint. Thereafter vaccines (prophylactic or therapeutic) still need global access and sufficient uptake to deliver impact and a key and necessary driver is education. |
| first_indexed | 2024-03-08T21:48:31Z |
| format | Article |
| id | doaj.art-e154e44940d843fdaecb4f5df6846a58 |
| institution | Directory Open Access Journal |
| issn | 2666-6790 |
| language | English |
| last_indexed | 2024-03-08T21:48:31Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tumour Virus Research |
| spelling | doaj.art-e154e44940d843fdaecb4f5df6846a582023-12-20T07:39:14ZengElsevierTumour Virus Research2666-67902023-12-0116200263Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia?Peter L. Stern0Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UKThe International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, clinical and public health research relating to animal and human papillomaviruses. This editorial is a personal reflection, it does not attempt to be comprehensive and reports on some key aspects centred on the prospects for immune interventions in prevention and treatment of HPV infections and early precancers with a focus on cervical neoplasia. There is optimism for the future impact of immunotherapy in treating early HPV associated disease. This will depend on developing an appropriate design of vaccines and delivery vehicles which then need to be properly tested in clinical trials that are able to measure a useful clinical endpoint. Thereafter vaccines (prophylactic or therapeutic) still need global access and sufficient uptake to deliver impact and a key and necessary driver is education.http://www.sciencedirect.com/science/article/pii/S2666679023000101 |
| spellingShingle | Peter L. Stern Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? Tumour Virus Research |
| title | Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? |
| title_full | Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? |
| title_fullStr | Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? |
| title_full_unstemmed | Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? |
| title_short | Is immunotherapy a potential game changer in managing human papillomavirus (HPV) infection and intraepithelial neoplasia? |
| title_sort | is immunotherapy a potential game changer in managing human papillomavirus hpv infection and intraepithelial neoplasia |
| url | http://www.sciencedirect.com/science/article/pii/S2666679023000101 |
| work_keys_str_mv | AT peterlstern isimmunotherapyapotentialgamechangerinmanaginghumanpapillomavirushpvinfectionandintraepithelialneoplasia |