Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review
We report a case of primary undifferentiated bladder carcinoma, which revealed a remarkable response to methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) therapy. A 46-year-old Japanese woman presented at the hospital with the chief complaints of gross hematuria and pain during urination....
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-11-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/369004 |
| _version_ | 1828351009287569408 |
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| author | Kenji Numahata Senji Hoshi Kiyotsugu Hoshi Nobuhiro Yasuno Maiko Kubo Isoji Sasagawa Shoichiro Ohta |
| author_facet | Kenji Numahata Senji Hoshi Kiyotsugu Hoshi Nobuhiro Yasuno Maiko Kubo Isoji Sasagawa Shoichiro Ohta |
| author_sort | Kenji Numahata |
| collection | DOAJ |
| description | We report a case of primary undifferentiated bladder carcinoma, which revealed a remarkable response to methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) therapy. A 46-year-old Japanese woman presented at the hospital with the chief complaints of gross hematuria and pain during urination. Cystoscopy revealed a large smooth-surfaced tumor in the urinary bladder. The histopathological diagnosis was undifferentiated carcinoma. The patient then received 3 courses of MVAC over a 3-month period. Hydronephrosis disappeared after the first course, and the tumor shrank rapidly. After completion of the third MVAC course, radical cystectomy and ileal conduit surgery were performed. After 7 years, the patient has still had no recurrences or metastases. We retrospectively review the relative efficacy of the two popular chemotherapeutic regimens in the management of muscle-invasive bladder cancer in patients who had had radical cystectomy. |
| first_indexed | 2024-04-14T01:33:19Z |
| format | Article |
| id | doaj.art-e1550c1626624404a7919aec2f87f6f3 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-14T01:33:19Z |
| publishDate | 2014-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-e1550c1626624404a7919aec2f87f6f32022-12-22T02:20:05ZengKarger PublishersCase Reports in Oncology1662-65752014-11-017374675010.1159/000369004369004Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature ReviewKenji NumahataSenji HoshiKiyotsugu HoshiNobuhiro YasunoMaiko KuboIsoji SasagawaShoichiro OhtaWe report a case of primary undifferentiated bladder carcinoma, which revealed a remarkable response to methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) therapy. A 46-year-old Japanese woman presented at the hospital with the chief complaints of gross hematuria and pain during urination. Cystoscopy revealed a large smooth-surfaced tumor in the urinary bladder. The histopathological diagnosis was undifferentiated carcinoma. The patient then received 3 courses of MVAC over a 3-month period. Hydronephrosis disappeared after the first course, and the tumor shrank rapidly. After completion of the third MVAC course, radical cystectomy and ileal conduit surgery were performed. After 7 years, the patient has still had no recurrences or metastases. We retrospectively review the relative efficacy of the two popular chemotherapeutic regimens in the management of muscle-invasive bladder cancer in patients who had had radical cystectomy.http://www.karger.com/Article/FullText/369004Undifferentiated bladder carcinomaMethotrexate, vinblastine, adriamycin, and cisplatinNeoadjuvant chemotherapy |
| spellingShingle | Kenji Numahata Senji Hoshi Kiyotsugu Hoshi Nobuhiro Yasuno Maiko Kubo Isoji Sasagawa Shoichiro Ohta Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review Case Reports in Oncology Undifferentiated bladder carcinoma Methotrexate, vinblastine, adriamycin, and cisplatin Neoadjuvant chemotherapy |
| title | Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review |
| title_full | Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review |
| title_fullStr | Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review |
| title_full_unstemmed | Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review |
| title_short | Remarkable Response to Neoadjuvant Therapy with Methotrexate, Vinblastine, Adriamycin, and Cisplatin for Undifferentiated Bladder Carcinoma: A Case Report and Literature Review |
| title_sort | remarkable response to neoadjuvant therapy with methotrexate vinblastine adriamycin and cisplatin for undifferentiated bladder carcinoma a case report and literature review |
| topic | Undifferentiated bladder carcinoma Methotrexate, vinblastine, adriamycin, and cisplatin Neoadjuvant chemotherapy |
| url | http://www.karger.com/Article/FullText/369004 |
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