Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population
Background: The purpose of this study is to investigate the genotype and allele distribution of MTHFR rs1801133 in the Chinese population, and to analyze the relationship between gene polymorphism of MTHFR rs1801133 and risk of childhood leukemia. Methods: Blood samples and clinical data of childhoo...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304645P.pdf |
| _version_ | 1797396417515356160 |
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| author | Peng Yin Wang Chengjun Wu Lin |
| author_facet | Peng Yin Wang Chengjun Wu Lin |
| author_sort | Peng Yin |
| collection | DOAJ |
| description | Background: The purpose of this study is to investigate the genotype and allele distribution of MTHFR rs1801133 in the Chinese population, and to analyze the relationship between gene polymorphism of MTHFR rs1801133 and risk of childhood leukemia. Methods: Blood samples and clinical data of childhood leukemia cases (n=1132) and age-matched healthy controls (n=1053) were collected. Genotypes and allele distribution of MTHFR rs1801133 were detected by PCR-RFLP. Logistic regression model was generated to analyze the relation between MTHFR rs1801133 and susceptibility to childhood leukemia and the chemotherapy response. Results: Age, sex, BMI and family history of tumor were comparable between childhood leukemia cases and healthy controls. Genotypes and allele distribution of MTHFR rs1801133 were remarkably correlated to the risk of childhood leukemia. Genotype risk of MTHFR rs1801133 was parallel to the susceptibility to childhood leukemia. Specifically, compared with people carrying AA allele of MTHFR rs1801133, higher risk of childhood leukemia may occur in people carrying AG+GG allele of MTHFR rs1801133 with a younger age (<15 years) or complete remission from chemotherapy. Conclusions: MTHFR rs1801133 gene polymorphism has a significant correlation with childhood leukemia. It is an important genetic susceptibility gene of childhood leukemia. The reliability of the results requires to be further validated by the high-quality research involving a large sample size in multi-center hospitals. |
| first_indexed | 2024-03-09T00:50:59Z |
| format | Article |
| id | doaj.art-e1589643be4a46cf97003cfc7573ad9f |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-09T00:50:59Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-e1589643be4a46cf97003cfc7573ad9f2023-12-11T17:15:36ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-0142464564910.5937/jomb0-416721452-82582304645PGene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese populationPeng Yin0Wang Chengjun1Wu Lin2Anhui Provincial Children's Hospital, Department of Pediatric Nephrology, Hefei, ChinaAnhui Provincial Children's Hospital, Department of Pediatric hematologic Oncology, Hefei, ChinaAnhui Provincial Children's Hospital, Department of Pediatric Nephrology, Hefei, ChinaBackground: The purpose of this study is to investigate the genotype and allele distribution of MTHFR rs1801133 in the Chinese population, and to analyze the relationship between gene polymorphism of MTHFR rs1801133 and risk of childhood leukemia. Methods: Blood samples and clinical data of childhood leukemia cases (n=1132) and age-matched healthy controls (n=1053) were collected. Genotypes and allele distribution of MTHFR rs1801133 were detected by PCR-RFLP. Logistic regression model was generated to analyze the relation between MTHFR rs1801133 and susceptibility to childhood leukemia and the chemotherapy response. Results: Age, sex, BMI and family history of tumor were comparable between childhood leukemia cases and healthy controls. Genotypes and allele distribution of MTHFR rs1801133 were remarkably correlated to the risk of childhood leukemia. Genotype risk of MTHFR rs1801133 was parallel to the susceptibility to childhood leukemia. Specifically, compared with people carrying AA allele of MTHFR rs1801133, higher risk of childhood leukemia may occur in people carrying AG+GG allele of MTHFR rs1801133 with a younger age (<15 years) or complete remission from chemotherapy. Conclusions: MTHFR rs1801133 gene polymorphism has a significant correlation with childhood leukemia. It is an important genetic susceptibility gene of childhood leukemia. The reliability of the results requires to be further validated by the high-quality research involving a large sample size in multi-center hospitals.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304645P.pdfmthfr rs1801133polymorphismchildhood leukemiagenetic susceptibility |
| spellingShingle | Peng Yin Wang Chengjun Wu Lin Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population Journal of Medical Biochemistry mthfr rs1801133 polymorphism childhood leukemia genetic susceptibility |
| title | Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population |
| title_full | Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population |
| title_fullStr | Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population |
| title_full_unstemmed | Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population |
| title_short | Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population |
| title_sort | gene polymorphism of mthfr rs1801133 and susceptibility to childhood leukemia in chinese population |
| topic | mthfr rs1801133 polymorphism childhood leukemia genetic susceptibility |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304645P.pdf |
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