The role of the KIBRA and APOE genes in developing spatial abilities in humans
In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2022-01-01
|
| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/3202 |
| _version_ | 1797213977252462592 |
|---|---|
| author | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. N. Mustafin Z. R. Takhirova S. B. Malykh M. M. Lobaskova T. N. Tikhomirova E. K. Khusnutdinova |
| author_facet | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. N. Mustafin Z. R. Takhirova S. B. Malykh M. M. Lobaskova T. N. Tikhomirova E. K. Khusnutdinova |
| author_sort | A. V. Kazantseva |
| collection | DOAJ |
| description | In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. Considering a significant role of genetic and environmental components in cognitive functioning, the present study aimed to estimate the main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265), GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect of gene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged 18–25 years (N = 1011, 80 % women). Spatial abilities were measured using a battery of cognitive tests including the assessment of “3D shape rotation” (mental rotation). Multiple regression analysis, which was carried out in the total sample controlling for sex, ethnicity and the presence of the “risk” APOE ε4 allele, demonstrated the association of the rs17070145 Т-allele in the KIBRA gene with enhanced spatial ability (β = 1.32; pFDR = 0.037) compared to carriers of the rs17070145 CC-genotype. The analysis of gene-environment interactions revealed that nicotine smoking (β = 3.74; p = 0.010) and urban/rural residency in childhood (β = –6.94; p = 0.0002) modulated the association of KIBRA rs17070145 and АРОЕ (rs7412, rs429358) gene variants with individual differences in mental rotation, respectively. The data obtained confirm the effect of the KIBRA rs17070145 Т-allele on improved cognitive functioning and for the first time evidence the association of the mentioned genetic variant with spatial abilities in humans. A “protective” effect of the APOE ε2 allele on enhanced cognitive functioning is observed only under certain conditions related to childhood rearing. |
| first_indexed | 2024-03-07T16:05:33Z |
| format | Article |
| id | doaj.art-e15897c21b034897a76e062c0d4aabcf |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2024-04-24T11:06:51Z |
| publishDate | 2022-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-e15897c21b034897a76e062c0d4aabcf2024-04-11T15:31:04ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592022-01-0125883984610.18699/VJ21.0971222The role of the KIBRA and APOE genes in developing spatial abilities in humansA. V. Kazantseva0R. F. Enikeeva1Yu. D. Davydova2R. N. Mustafin3Z. R. Takhirova4S. B. Malykh5M. M. Lobaskova6T. N. Tikhomirova7E. K. Khusnutdinova8Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Ufa State Petroleum Technological University, Department of molecular technologiesInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesBashkir State Medical University, Department of medical genetics and fundamental medicineBashkir State University, Department of genetics and fundamental medicinePsychological Institute of the Russian Academy of Education; Lomonosov Moscow State University, Department of psychologyPsychological Institute of the Russian Academy of EducationPsychological Institute of the Russian Academy of Education; Lomonosov Moscow State University, Department of psychologyInstitute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Lomonosov Moscow State University, Department of psychologyIn the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. Considering a significant role of genetic and environmental components in cognitive functioning, the present study aimed to estimate the main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265), GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect of gene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged 18–25 years (N = 1011, 80 % women). Spatial abilities were measured using a battery of cognitive tests including the assessment of “3D shape rotation” (mental rotation). Multiple regression analysis, which was carried out in the total sample controlling for sex, ethnicity and the presence of the “risk” APOE ε4 allele, demonstrated the association of the rs17070145 Т-allele in the KIBRA gene with enhanced spatial ability (β = 1.32; pFDR = 0.037) compared to carriers of the rs17070145 CC-genotype. The analysis of gene-environment interactions revealed that nicotine smoking (β = 3.74; p = 0.010) and urban/rural residency in childhood (β = –6.94; p = 0.0002) modulated the association of KIBRA rs17070145 and АРОЕ (rs7412, rs429358) gene variants with individual differences in mental rotation, respectively. The data obtained confirm the effect of the KIBRA rs17070145 Т-allele on improved cognitive functioning and for the first time evidence the association of the mentioned genetic variant with spatial abilities in humans. A “protective” effect of the APOE ε2 allele on enhanced cognitive functioning is observed only under certain conditions related to childhood rearing.https://vavilov.elpub.ru/jour/article/view/3202kibraapoecognitive abilitiesmental rotationlinear regressiongene-environment interactions |
| spellingShingle | A. V. Kazantseva R. F. Enikeeva Yu. D. Davydova R. N. Mustafin Z. R. Takhirova S. B. Malykh M. M. Lobaskova T. N. Tikhomirova E. K. Khusnutdinova The role of the KIBRA and APOE genes in developing spatial abilities in humans Вавиловский журнал генетики и селекции kibra apoe cognitive abilities mental rotation linear regression gene-environment interactions |
| title | The role of the KIBRA and APOE genes in developing spatial abilities in humans |
| title_full | The role of the KIBRA and APOE genes in developing spatial abilities in humans |
| title_fullStr | The role of the KIBRA and APOE genes in developing spatial abilities in humans |
| title_full_unstemmed | The role of the KIBRA and APOE genes in developing spatial abilities in humans |
| title_short | The role of the KIBRA and APOE genes in developing spatial abilities in humans |
| title_sort | role of the kibra and apoe genes in developing spatial abilities in humans |
| topic | kibra apoe cognitive abilities mental rotation linear regression gene-environment interactions |
| url | https://vavilov.elpub.ru/jour/article/view/3202 |
| work_keys_str_mv | AT avkazantseva theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT rfenikeeva theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT yuddavydova theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT rnmustafin theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT zrtakhirova theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT sbmalykh theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT mmlobaskova theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT tntikhomirova theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT ekkhusnutdinova theroleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT avkazantseva roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT rfenikeeva roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT yuddavydova roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT rnmustafin roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT zrtakhirova roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT sbmalykh roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT mmlobaskova roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT tntikhomirova roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans AT ekkhusnutdinova roleofthekibraandapoegenesindevelopingspatialabilitiesinhumans |