Analysis on pathogenesis of keratoconus with chronic corneal trauma
Keratoconus is a progressive, non-inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-08-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://www.ies.net.cn/cn_publish/2014/8/201408011.pdf |
| _version_ | 1818825650735153152 |
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| author | Qi Wan Ying-Ping Deng |
| author_facet | Qi Wan Ying-Ping Deng |
| author_sort | Qi Wan |
| collection | DOAJ |
| description | Keratoconus is a progressive, non-inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but environmental factors, such as abnormal rubbing, contact lens wearing and ultraviolet radiation may be easily ignored. Although it is commonly thought that keratoconus is a result of various pathological progress mediated by multiple factors, those chronic trauma could play important roles in the pathological progress. The classic definition of keratoconus is still referred as a non-inflammation disorder with malnutrition of keratectasia, more and more clinical evidences and experimental results that may refute this concept. It may be due to the long-term persistent chronic trauma resulted from eye rubbing, contact lens or ultraviolet radiation. Under this conditions, the increased release of inflammatory mediators and matrix metalloproteinases may accelerate keratocyte apoposis and enzyme metabolism disorders, with the result of matrix cell lost, tensile strength decreased and keratectasia. Here, for some papers known about the relationship between chronic cornea trauma and keratoconus were reviewed and discussed its possible causal relationship. |
| first_indexed | 2024-12-19T00:15:09Z |
| format | Article |
| id | doaj.art-e159241370b845a2abafb9943b88a9de |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-19T00:15:09Z |
| publishDate | 2014-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-e159241370b845a2abafb9943b88a9de2022-12-21T20:45:51ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232014-08-011481410141210.3980/j.issn.1672-5123.2014.08.11Analysis on pathogenesis of keratoconus with chronic corneal traumaQi Wan0Ying-Ping Deng1Department of Ophthalmology, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University,Chengdu 610041, Sichuan Province, ChinaKeratoconus is a progressive, non-inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but environmental factors, such as abnormal rubbing, contact lens wearing and ultraviolet radiation may be easily ignored. Although it is commonly thought that keratoconus is a result of various pathological progress mediated by multiple factors, those chronic trauma could play important roles in the pathological progress. The classic definition of keratoconus is still referred as a non-inflammation disorder with malnutrition of keratectasia, more and more clinical evidences and experimental results that may refute this concept. It may be due to the long-term persistent chronic trauma resulted from eye rubbing, contact lens or ultraviolet radiation. Under this conditions, the increased release of inflammatory mediators and matrix metalloproteinases may accelerate keratocyte apoposis and enzyme metabolism disorders, with the result of matrix cell lost, tensile strength decreased and keratectasia. Here, for some papers known about the relationship between chronic cornea trauma and keratoconus were reviewed and discussed its possible causal relationship.http://www.ies.net.cn/cn_publish/2014/8/201408011.pdfchronic traumainflammationcorneakeratoconus |
| spellingShingle | Qi Wan Ying-Ping Deng Analysis on pathogenesis of keratoconus with chronic corneal trauma Guoji Yanke Zazhi chronic trauma inflammation cornea keratoconus |
| title | Analysis on pathogenesis of keratoconus with chronic corneal trauma |
| title_full | Analysis on pathogenesis of keratoconus with chronic corneal trauma |
| title_fullStr | Analysis on pathogenesis of keratoconus with chronic corneal trauma |
| title_full_unstemmed | Analysis on pathogenesis of keratoconus with chronic corneal trauma |
| title_short | Analysis on pathogenesis of keratoconus with chronic corneal trauma |
| title_sort | analysis on pathogenesis of keratoconus with chronic corneal trauma |
| topic | chronic trauma inflammation cornea keratoconus |
| url | http://www.ies.net.cn/cn_publish/2014/8/201408011.pdf |
| work_keys_str_mv | AT qiwan analysisonpathogenesisofkeratoconuswithchroniccornealtrauma AT yingpingdeng analysisonpathogenesisofkeratoconuswithchroniccornealtrauma |