Clinical value of station 4R node dissection in esophageal squamous cell carcinoma
Abstract Background Many controversies still exist concerning the optimal extent of lymphadenectomy during esophagectomy in esophageal squamous cell carcinoma (ESCC). The objective of this study was to explore the characteristics of 4R metastasis and evaluate the clinical value of 4R node dissection...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03280-7 |
| _version_ | 1797377009309974528 |
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| author | Xin-ye Wang Xia-yu Fu Hong Yang Jing Wen Peng Lin Jian-hua Fu |
| author_facet | Xin-ye Wang Xia-yu Fu Hong Yang Jing Wen Peng Lin Jian-hua Fu |
| author_sort | Xin-ye Wang |
| collection | DOAJ |
| description | Abstract Background Many controversies still exist concerning the optimal extent of lymphadenectomy during esophagectomy in esophageal squamous cell carcinoma (ESCC). The objective of this study was to explore the characteristics of 4R metastasis and evaluate the clinical value of 4R node dissection in ESCC. Methods A total of 736 ESCC patients who underwent radical esophagectomy between 2005 and 2013 were retrospectively collected, among which 393 ones underwent 4R dissection. Propensity score matching (PSM) method was applied to reduce the effects of confounding variables between the 4R dissection and non-dissection groups to analyze overall survival. Results Patients showed a low 4R metastasis rate of 5.1% (20/393) (5.2%, 5.8%, and 1.8% for upper, middle, and lower tumors, respectively). Correlation analyses identified that 4R metastasis was significantly associated with station 2R metastasis (p < 0.001) and pathologic tumor-node-metastasis (pTNM) stage (p < 0.001). All 4R metastases were observed in stages IIIB and IVA. Moreover, patients with station 4R dissection failed to achieve significantly improved overall survival compared with those without 4R dissection, regardless of tumor stage (overall: p = 0.696; stage 0-IIIA: p = 0.317; stage IIIB-IVA: p = 0.619). Conclusion 4R metastasis is likely to be associated with more aggressive disease, and routine 4R node dissection might not be necessary for ESCC patients. |
| first_indexed | 2024-03-08T19:46:47Z |
| format | Article |
| id | doaj.art-e15962a5c7294e74b466f9751a0c6294 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-08T19:46:47Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-e15962a5c7294e74b466f9751a0c62942023-12-24T12:20:32ZengBMCWorld Journal of Surgical Oncology1477-78192023-12-0121111010.1186/s12957-023-03280-7Clinical value of station 4R node dissection in esophageal squamous cell carcinomaXin-ye Wang0Xia-yu Fu1Hong Yang2Jing Wen3Peng Lin4Jian-hua Fu5Department of Thoracic Surgery, Sun Yat-Sen University Cancer CenterDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer CenterDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer CenterDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer CenterDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer CenterDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer CenterAbstract Background Many controversies still exist concerning the optimal extent of lymphadenectomy during esophagectomy in esophageal squamous cell carcinoma (ESCC). The objective of this study was to explore the characteristics of 4R metastasis and evaluate the clinical value of 4R node dissection in ESCC. Methods A total of 736 ESCC patients who underwent radical esophagectomy between 2005 and 2013 were retrospectively collected, among which 393 ones underwent 4R dissection. Propensity score matching (PSM) method was applied to reduce the effects of confounding variables between the 4R dissection and non-dissection groups to analyze overall survival. Results Patients showed a low 4R metastasis rate of 5.1% (20/393) (5.2%, 5.8%, and 1.8% for upper, middle, and lower tumors, respectively). Correlation analyses identified that 4R metastasis was significantly associated with station 2R metastasis (p < 0.001) and pathologic tumor-node-metastasis (pTNM) stage (p < 0.001). All 4R metastases were observed in stages IIIB and IVA. Moreover, patients with station 4R dissection failed to achieve significantly improved overall survival compared with those without 4R dissection, regardless of tumor stage (overall: p = 0.696; stage 0-IIIA: p = 0.317; stage IIIB-IVA: p = 0.619). Conclusion 4R metastasis is likely to be associated with more aggressive disease, and routine 4R node dissection might not be necessary for ESCC patients.https://doi.org/10.1186/s12957-023-03280-7Esophageal squamous cell carcinoma (ESCC)Station 4RClinical value |
| spellingShingle | Xin-ye Wang Xia-yu Fu Hong Yang Jing Wen Peng Lin Jian-hua Fu Clinical value of station 4R node dissection in esophageal squamous cell carcinoma World Journal of Surgical Oncology Esophageal squamous cell carcinoma (ESCC) Station 4R Clinical value |
| title | Clinical value of station 4R node dissection in esophageal squamous cell carcinoma |
| title_full | Clinical value of station 4R node dissection in esophageal squamous cell carcinoma |
| title_fullStr | Clinical value of station 4R node dissection in esophageal squamous cell carcinoma |
| title_full_unstemmed | Clinical value of station 4R node dissection in esophageal squamous cell carcinoma |
| title_short | Clinical value of station 4R node dissection in esophageal squamous cell carcinoma |
| title_sort | clinical value of station 4r node dissection in esophageal squamous cell carcinoma |
| topic | Esophageal squamous cell carcinoma (ESCC) Station 4R Clinical value |
| url | https://doi.org/10.1186/s12957-023-03280-7 |
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