Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections
Urinary tract infections (UTIs) mainly caused by Uropathogenic Escherichia coli (UPEC), are common bacterial infections. Many individuals suffer from chronically recurring UTIs, sometimes requiring long-term prophylactic antibiotic regimens. The global emergence of multi-drug resistant uropathogens...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.01509/full |
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| author | Paul Loubet Jérémy Ranfaing Aurélien Dinh Catherine Dunyach-Remy Louis Bernard Louis Bernard Franck Bruyère Franck Bruyère Jean-Philippe Lavigne Albert Sotto |
| author_facet | Paul Loubet Jérémy Ranfaing Aurélien Dinh Catherine Dunyach-Remy Louis Bernard Louis Bernard Franck Bruyère Franck Bruyère Jean-Philippe Lavigne Albert Sotto |
| author_sort | Paul Loubet |
| collection | DOAJ |
| description | Urinary tract infections (UTIs) mainly caused by Uropathogenic Escherichia coli (UPEC), are common bacterial infections. Many individuals suffer from chronically recurring UTIs, sometimes requiring long-term prophylactic antibiotic regimens. The global emergence of multi-drug resistant uropathogens in the last decade underlines the need for alternative non-antibiotic therapeutic and preventative strategies against UTIs. The research on non-antibiotic therapeutic options in UTIs has focused on the following phases of the pathogenesis: colonization, adherence of pathogens to uroepithelial cell receptors and invasion. In this review, we discuss vaccines, small compounds, nutraceuticals, immunomodulating agents, probiotics and bacteriophages, highlighting the challenges each of these approaches face. Most of these treatments show interesting but only preliminary results. Lactobacillus-containing products and cranberry products in conjunction with propolis have shown the most robust results to date and appear to be the most promising new alternative to currently used antibiotics. Larger efficacy clinical trials as well as studies on the interplay between non-antibiotic therapies, uropathogens and the host immune system are warranted. |
| first_indexed | 2024-12-23T20:08:50Z |
| format | Article |
| id | doaj.art-e15afbfe7fc1406790acca59069975e3 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-23T20:08:50Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e15afbfe7fc1406790acca59069975e32022-12-21T17:32:52ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-07-011110.3389/fmicb.2020.01509515350Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract InfectionsPaul Loubet0Jérémy Ranfaing1Aurélien Dinh2Catherine Dunyach-Remy3Louis Bernard4Louis Bernard5Franck Bruyère6Franck Bruyère7Jean-Philippe Lavigne8Albert Sotto9VBMI, INSERM U1047, Université de Montpellier, Service des Maladies Infectieuses et Tropicales, CHU Nîmes, Nîmes, FranceVBMI, INSERM U1047, Université de Montpellier, Service de Microbiologie et Hygiène Hospitalière, CHU Nîmes, Nîmes, FranceService des Maladies Infectieuses, AP-HP Raymond-Poincaré, Garches, FranceVBMI, INSERM U1047, Université de Montpellier, Service de Microbiologie et Hygiène Hospitalière, CHU Nîmes, Nîmes, FrancePRES Centre Val de Loire, Université François Rabelais de Tours, Tours, FranceService des Maladies Infectieuses, CHU Tours, Tours, FrancePRES Centre Val de Loire, Université François Rabelais de Tours, Tours, FranceService d’Urologie, CHU Tours, Tours, FranceVBMI, INSERM U1047, Université de Montpellier, Service de Microbiologie et Hygiène Hospitalière, CHU Nîmes, Nîmes, FranceVBMI, INSERM U1047, Université de Montpellier, Service des Maladies Infectieuses et Tropicales, CHU Nîmes, Nîmes, FranceUrinary tract infections (UTIs) mainly caused by Uropathogenic Escherichia coli (UPEC), are common bacterial infections. Many individuals suffer from chronically recurring UTIs, sometimes requiring long-term prophylactic antibiotic regimens. The global emergence of multi-drug resistant uropathogens in the last decade underlines the need for alternative non-antibiotic therapeutic and preventative strategies against UTIs. The research on non-antibiotic therapeutic options in UTIs has focused on the following phases of the pathogenesis: colonization, adherence of pathogens to uroepithelial cell receptors and invasion. In this review, we discuss vaccines, small compounds, nutraceuticals, immunomodulating agents, probiotics and bacteriophages, highlighting the challenges each of these approaches face. Most of these treatments show interesting but only preliminary results. Lactobacillus-containing products and cranberry products in conjunction with propolis have shown the most robust results to date and appear to be the most promising new alternative to currently used antibiotics. Larger efficacy clinical trials as well as studies on the interplay between non-antibiotic therapies, uropathogens and the host immune system are warranted.https://www.frontiersin.org/article/10.3389/fmicb.2020.01509/fullurinary tract infectionalternative therapeuticsvaccinesnutraceuticalsimmunomodulating agentsprobiotics |
| spellingShingle | Paul Loubet Jérémy Ranfaing Aurélien Dinh Catherine Dunyach-Remy Louis Bernard Louis Bernard Franck Bruyère Franck Bruyère Jean-Philippe Lavigne Albert Sotto Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections Frontiers in Microbiology urinary tract infection alternative therapeutics vaccines nutraceuticals immunomodulating agents probiotics |
| title | Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections |
| title_full | Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections |
| title_fullStr | Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections |
| title_full_unstemmed | Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections |
| title_short | Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections |
| title_sort | alternative therapeutic options to antibiotics for the treatment of urinary tract infections |
| topic | urinary tract infection alternative therapeutics vaccines nutraceuticals immunomodulating agents probiotics |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2020.01509/full |
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