Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score
Background: Thyroid-stimulating hormone (TSH) suppression therapy is an important treatment modality for differentiated thyroid carcinoma (DTC), but it increases fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopaus...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/9/1964 |
| _version_ | 1797535390463164416 |
|---|---|
| author | Chae Won Chung Hoon Sung Choi Sung Hye Kong Young Joo Park Do Joon Park Hwa Young Ahn Sun Wook Cho |
| author_facet | Chae Won Chung Hoon Sung Choi Sung Hye Kong Young Joo Park Do Joon Park Hwa Young Ahn Sun Wook Cho |
| author_sort | Chae Won Chung |
| collection | DOAJ |
| description | Background: Thyroid-stimulating hormone (TSH) suppression therapy is an important treatment modality for differentiated thyroid carcinoma (DTC), but it increases fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy. Methods: A total of 410 postmenopausal DTC patients who underwent thyroidectomy and had at least two dual-energy X-ray absorptiometry measurements, including a preoperative measurement, were included. Patients who had osteoporosis medication for more than 1 year were classified as ‘patients with osteoporosis’. Results: In patients without osteoporosis, the change in %BMD was similar between TSH suppression (−) and (+) groups, while the decrease in %TBS was significantly greater in the TSH suppression (+) group than that of the TSH suppression (−) group. The relative risk of vertebral fracture was decreased by TBS changes but not by BMD changes. In patients with osteoporosis, both BMD and TBS showed significant increases in the TSH suppression (−) group but not in TSH suppression (+) group. At year 4, TBS was significantly lower in the TSH suppression (+) group than that in the TSH suppression (−) group, while BMD showed no difference between groups. Conclusions: TBS may better reflect bone health than BMD in postmenopausal DTC patients with TSH suppression therapy. |
| first_indexed | 2024-03-10T11:43:49Z |
| format | Article |
| id | doaj.art-e15b07372e014caca59dbf00b788b83e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:43:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e15b07372e014caca59dbf00b788b83e2023-11-21T18:18:12ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-01109196410.3390/jcm10091964Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone ScoreChae Won Chung0Hoon Sung Choi1Sung Hye Kong2Young Joo Park3Do Joon Park4Hwa Young Ahn5Sun Wook Cho6Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Kangwon National University Hospital, Chuncheon-si 24289, KoreaDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Chung-Ang University Hospital, Seoul 06973, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaBackground: Thyroid-stimulating hormone (TSH) suppression therapy is an important treatment modality for differentiated thyroid carcinoma (DTC), but it increases fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy. Methods: A total of 410 postmenopausal DTC patients who underwent thyroidectomy and had at least two dual-energy X-ray absorptiometry measurements, including a preoperative measurement, were included. Patients who had osteoporosis medication for more than 1 year were classified as ‘patients with osteoporosis’. Results: In patients without osteoporosis, the change in %BMD was similar between TSH suppression (−) and (+) groups, while the decrease in %TBS was significantly greater in the TSH suppression (+) group than that of the TSH suppression (−) group. The relative risk of vertebral fracture was decreased by TBS changes but not by BMD changes. In patients with osteoporosis, both BMD and TBS showed significant increases in the TSH suppression (−) group but not in TSH suppression (+) group. At year 4, TBS was significantly lower in the TSH suppression (+) group than that in the TSH suppression (−) group, while BMD showed no difference between groups. Conclusions: TBS may better reflect bone health than BMD in postmenopausal DTC patients with TSH suppression therapy.https://www.mdpi.com/2077-0383/10/9/1964differentiated thyroid carcinomabone mineral densitytrabecular bone scoreTSH suppression therapy |
| spellingShingle | Chae Won Chung Hoon Sung Choi Sung Hye Kong Young Joo Park Do Joon Park Hwa Young Ahn Sun Wook Cho Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score Journal of Clinical Medicine differentiated thyroid carcinoma bone mineral density trabecular bone score TSH suppression therapy |
| title | Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score |
| title_full | Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score |
| title_fullStr | Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score |
| title_full_unstemmed | Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score |
| title_short | Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma: Bone Mineral Density versus the Trabecular Bone Score |
| title_sort | measurements of bone health after thyroid stimulating suppression therapy in postmenopausal women with differentiated thyroid carcinoma bone mineral density versus the trabecular bone score |
| topic | differentiated thyroid carcinoma bone mineral density trabecular bone score TSH suppression therapy |
| url | https://www.mdpi.com/2077-0383/10/9/1964 |
| work_keys_str_mv | AT chaewonchung measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT hoonsungchoi measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT sunghyekong measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT youngjoopark measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT dojoonpark measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT hwayoungahn measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore AT sunwookcho measurementsofbonehealthafterthyroidstimulatingsuppressiontherapyinpostmenopausalwomenwithdifferentiatedthyroidcarcinomabonemineraldensityversusthetrabecularbonescore |