Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats
Introduction: It has shown that listening to Mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iran University of Medical Sciences
2011-04-01
|
| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-8-3&slc_lang=en&sid=1 |
| _version_ | 1827333523799801856 |
|---|---|
| author | Mohsen Marzban Ali Shahbazi Mahdi Tondar Mansooreh Soleimani Masoomeh Bakhshayesh Arash Moshkforoush Mehdi Sadati Siamak Alizadeh Zendehrood Mohammad Taghi Joghataei |
| author_facet | Mohsen Marzban Ali Shahbazi Mahdi Tondar Mansooreh Soleimani Masoomeh Bakhshayesh Arash Moshkforoush Mehdi Sadati Siamak Alizadeh Zendehrood Mohammad Taghi Joghataei |
| author_sort | Mohsen Marzban |
| collection | DOAJ |
| description | Introduction: It has shown that listening to Mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the hippocampus. Here we investigated the effect of postpartum exposure to The Mozart music on BDNF concentration in the hippocampus of rat.Methods: Thirty male one day old newborn Wistar rats divided randomly in two equal experimental and control groups. Experimental group exposed to slow rhythm Mozart music (Mozart Sonata for two pianos KV 448, 6 hour per day sound pressure levels, between 80 and 100 dB) for 60 successive days. The control group was kept in separate room with housing conditions like experimental group except music exposure. After 60 days the rats were euthanized and hippocampuses extracted then the content of BDNF protein was measured using ELISA sandwich method. Results: Data analysis revealed that rats exposed to Mozart Sonata music had significantly increased BDNF content in the hippocampus as compared to control rats (P±0.01). The concentrations of BDNF were 86.30±2.26 and 94.60 ±6.22 ng/g wet weight in control and music exposure groups respectively.Discussion: Exposure to the Mozart music early in life can increase the BDNF concentration in the hippocampus in rats. |
| first_indexed | 2024-03-07T17:26:40Z |
| format | Article |
| id | doaj.art-e15c51a0d66f4da196a758885ad62edc |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:26:40Z |
| publishDate | 2011-04-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-e15c51a0d66f4da196a758885ad62edc2024-03-02T19:07:06ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-04-01232126Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal RatsMohsen Marzban0Ali Shahbazi1Mahdi Tondar2Mansooreh Soleimani3Masoomeh Bakhshayesh4Arash Moshkforoush5Mehdi Sadati6Siamak Alizadeh Zendehrood7Mohammad Taghi Joghataei8 Introduction: It has shown that listening to Mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. A few studies have reported the effects of prenatal plus postpartum exposure of mice to the Mozart music on brain-drived neurotrophic factor (BDNF) in the hippocampus. Here we investigated the effect of postpartum exposure to The Mozart music on BDNF concentration in the hippocampus of rat.Methods: Thirty male one day old newborn Wistar rats divided randomly in two equal experimental and control groups. Experimental group exposed to slow rhythm Mozart music (Mozart Sonata for two pianos KV 448, 6 hour per day sound pressure levels, between 80 and 100 dB) for 60 successive days. The control group was kept in separate room with housing conditions like experimental group except music exposure. After 60 days the rats were euthanized and hippocampuses extracted then the content of BDNF protein was measured using ELISA sandwich method. Results: Data analysis revealed that rats exposed to Mozart Sonata music had significantly increased BDNF content in the hippocampus as compared to control rats (P±0.01). The concentrations of BDNF were 86.30±2.26 and 94.60 ±6.22 ng/g wet weight in control and music exposure groups respectively.Discussion: Exposure to the Mozart music early in life can increase the BDNF concentration in the hippocampus in rats.http://bcn.iums.ac.ir/browse.php?a_code=A-10-8-3&slc_lang=en&sid=1Mozart MusicBDNFHippocampusRat |
| spellingShingle | Mohsen Marzban Ali Shahbazi Mahdi Tondar Mansooreh Soleimani Masoomeh Bakhshayesh Arash Moshkforoush Mehdi Sadati Siamak Alizadeh Zendehrood Mohammad Taghi Joghataei Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats Basic and Clinical Neuroscience Mozart Music BDNF Hippocampus Rat |
| title | Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats |
| title_full | Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats |
| title_fullStr | Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats |
| title_full_unstemmed | Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats |
| title_short | Effect of Mozart Music on Hippocampal Content of BDNF in Postnatal Rats |
| title_sort | effect of mozart music on hippocampal content of bdnf in postnatal rats |
| topic | Mozart Music BDNF Hippocampus Rat |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-8-3&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mohsenmarzban effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT alishahbazi effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT mahditondar effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT mansoorehsoleimani effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT masoomehbakhshayesh effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT arashmoshkforoush effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT mehdisadati effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT siamakalizadehzendehrood effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats AT mohammadtaghijoghataei effectofmozartmusiconhippocampalcontentofbdnfinpostnatalrats |