Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system
Mast cell tumours (MCTs) arise in the dermis and subcutaneous tissues in animals and humans and are one of the most common neoplasms of the skin in dogs. Cannabinoid type 2 receptor (CB2R), cyclin-dependent kinase inhibitor (p21) and matrix metalloproteinase 1 (MMP-1) are potential targets for novel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-12-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2023-0066 |
| _version_ | 1797375898232553472 |
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| author | Bulak Kamila Kycko Anna Śmiech Anna Łopuszyński Wojciech |
| author_facet | Bulak Kamila Kycko Anna Śmiech Anna Łopuszyński Wojciech |
| author_sort | Bulak Kamila |
| collection | DOAJ |
| description | Mast cell tumours (MCTs) arise in the dermis and subcutaneous tissues in animals and humans and are one of the most common neoplasms of the skin in dogs. Cannabinoid type 2 receptor (CB2R), cyclin-dependent kinase inhibitor (p21) and matrix metalloproteinase 1 (MMP-1) are potential targets for novel anti-tumour therapeutic strategies. This study evaluated by immunohistochemical means the reactivity of p21, MMP-1 and CB2R proteins in association with a three-tier grading system in cutaneous canine MCTs. |
| first_indexed | 2024-03-08T19:30:54Z |
| format | Article |
| id | doaj.art-e15cf7e8e15e4c029aaf7a96a6ace2ac |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-03-08T19:30:54Z |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-e15cf7e8e15e4c029aaf7a96a6ace2ac2023-12-26T07:42:47ZengSciendoJournal of Veterinary Research2450-86082023-12-0167461161810.2478/jvetres-2023-0066Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading systemBulak Kamila0Kycko Anna1Śmiech Anna2Łopuszyński Wojciech31Department of Pathomorphology and Forensic Veterinary Medicine, University of Life Sciences in Lublin, 20-612Lublin, Poland2Department of Pathology, National Veterinary Research Institute, 24-100Puławy, Poland1Department of Pathomorphology and Forensic Veterinary Medicine, University of Life Sciences in Lublin, 20-612Lublin, Poland1Department of Pathomorphology and Forensic Veterinary Medicine, University of Life Sciences in Lublin, 20-612Lublin, PolandMast cell tumours (MCTs) arise in the dermis and subcutaneous tissues in animals and humans and are one of the most common neoplasms of the skin in dogs. Cannabinoid type 2 receptor (CB2R), cyclin-dependent kinase inhibitor (p21) and matrix metalloproteinase 1 (MMP-1) are potential targets for novel anti-tumour therapeutic strategies. This study evaluated by immunohistochemical means the reactivity of p21, MMP-1 and CB2R proteins in association with a three-tier grading system in cutaneous canine MCTs.https://doi.org/10.2478/jvetres-2023-0066mast cell tumourmmp-1 proteinp21 proteincb2 receptor proteincannabinoid |
| spellingShingle | Bulak Kamila Kycko Anna Śmiech Anna Łopuszyński Wojciech Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system Journal of Veterinary Research mast cell tumour mmp-1 protein p21 protein cb2 receptor protein cannabinoid |
| title | Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system |
| title_full | Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system |
| title_fullStr | Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system |
| title_full_unstemmed | Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system |
| title_short | Immunoreactivity of p21, MMP-1 and CB2 receptor proteins in cutaneous canine mast cell tumours: an association with the three-tier grading system |
| title_sort | immunoreactivity of p21 mmp 1 and cb2 receptor proteins in cutaneous canine mast cell tumours an association with the three tier grading system |
| topic | mast cell tumour mmp-1 protein p21 protein cb2 receptor protein cannabinoid |
| url | https://doi.org/10.2478/jvetres-2023-0066 |
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