The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study
IntroductionMillions of Americans are admitted to the intensive care unit (ICU) per year. Many survivors of the ICU will experience posttraumatic stress disorder (PTSD); although volumetric hippocampal and amygdala studies have been conducted in other trauma survivors (i.e., veterans), the associati...
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| Format: | Article |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00690/full |
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| author | Kristina Stepanovic Kristina Stepanovic Baxter Rogers Baxter Rogers Baxter Rogers Baxter Rogers Amy L. Kiehl Amy L. Kiehl Amy L. Kiehl E. Wesley Ely E. Wesley Ely E. Wesley Ely E. Wesley Ely James Jackson James Jackson James Jackson James Jackson Jo Ellen Wilson Jo Ellen Wilson for the VISIONS Investigators and VISualizing Icu SurvivOrs Neuroradiological Sequelae Cohort Study |
| author_facet | Kristina Stepanovic Kristina Stepanovic Baxter Rogers Baxter Rogers Baxter Rogers Baxter Rogers Amy L. Kiehl Amy L. Kiehl Amy L. Kiehl E. Wesley Ely E. Wesley Ely E. Wesley Ely E. Wesley Ely James Jackson James Jackson James Jackson James Jackson Jo Ellen Wilson Jo Ellen Wilson for the VISIONS Investigators and VISualizing Icu SurvivOrs Neuroradiological Sequelae Cohort Study |
| author_sort | Kristina Stepanovic |
| collection | DOAJ |
| description | IntroductionMillions of Americans are admitted to the intensive care unit (ICU) per year. Many survivors of the ICU will experience posttraumatic stress disorder (PTSD); although volumetric hippocampal and amygdala studies have been conducted in other trauma survivors (i.e., veterans), the association between PTSD symptoms and hippocampal and amygdala volumes in ICU survivors has not been described. We hypothesize that the severity of posttraumatic stress symptoms in ICU survivors is associated with lower volumes of both the hippocampus and amygdala at 3 and 12 months.MethodsSecondary analysis of the VISIONS study, a prospective sub-study of the BRAIN-ICU cohort, which included survivors of critical illness. The PTSD Checklist Specific was used at 3 and 12 months to evaluate the ICU as a traumatic experience. A Philips Achieva 3T MRI scanner was used to scan patients at both discharge and 3 months. To compare median brain volumes at discharge and 3 months for those with and without PTSD symptomatology, we used a Kruskal–Wallis (KW) test.ResultsAt 3 month follow up, three patients had PTSD symptomatology and N = 1 at 12 month follow up. There was no difference between median brain volumes (hippocampus or amygdala) between individuals with PTSD symptomatology at either 3 or 12 months (p-values > 0.05).DiscussionAlthough our study did not reveal significant differences in brain volumes between PTSD patients and non-PTSD patients, sample size was a major limitation and larger scale studies should be undertaken to elucidate possible neurobiological markers of PTSD in ICU survivors. |
| first_indexed | 2024-12-18T15:00:26Z |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-18T15:00:26Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj.art-e15e0d0ad2424e0a821389e4bf20aac42022-12-21T21:03:55ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-06-011410.3389/fnins.2020.00690526836The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary StudyKristina Stepanovic0Kristina Stepanovic1Baxter Rogers2Baxter Rogers3Baxter Rogers4Baxter Rogers5Amy L. Kiehl6Amy L. Kiehl7Amy L. Kiehl8E. Wesley Ely9E. Wesley Ely10E. Wesley Ely11E. Wesley Ely12James Jackson13James Jackson14James Jackson15James Jackson16Jo Ellen Wilson17Jo Ellen Wilson18for the VISIONS Investigators and VISualizing Icu SurvivOrs Neuroradiological Sequelae Cohort StudyCenter for Critical Illness Brain Dysfunction and Survivorship, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesVanderbilt University Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN, United StatesDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United StatesCenter for Critical Illness Brain Dysfunction and Survivorship, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Division of Pulmonary and Critical Care, and the Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United StatesCenter for Critical Illness Brain Dysfunction and Survivorship, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Division of Pulmonary and Critical Care, and the Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United StatesVeteran’s Affairs TN Valley, Geriatrics Research, Education and Clinical Center, Nashville, TN, United StatesCenter for Critical Illness Brain Dysfunction and Survivorship, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Division of Pulmonary and Critical Care, and the Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, United StatesVeteran’s Affairs TN Valley, Geriatrics Research, Education and Clinical Center, Nashville, TN, United StatesCenter for Critical Illness Brain Dysfunction and Survivorship, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United StatesIntroductionMillions of Americans are admitted to the intensive care unit (ICU) per year. Many survivors of the ICU will experience posttraumatic stress disorder (PTSD); although volumetric hippocampal and amygdala studies have been conducted in other trauma survivors (i.e., veterans), the association between PTSD symptoms and hippocampal and amygdala volumes in ICU survivors has not been described. We hypothesize that the severity of posttraumatic stress symptoms in ICU survivors is associated with lower volumes of both the hippocampus and amygdala at 3 and 12 months.MethodsSecondary analysis of the VISIONS study, a prospective sub-study of the BRAIN-ICU cohort, which included survivors of critical illness. The PTSD Checklist Specific was used at 3 and 12 months to evaluate the ICU as a traumatic experience. A Philips Achieva 3T MRI scanner was used to scan patients at both discharge and 3 months. To compare median brain volumes at discharge and 3 months for those with and without PTSD symptomatology, we used a Kruskal–Wallis (KW) test.ResultsAt 3 month follow up, three patients had PTSD symptomatology and N = 1 at 12 month follow up. There was no difference between median brain volumes (hippocampus or amygdala) between individuals with PTSD symptomatology at either 3 or 12 months (p-values > 0.05).DiscussionAlthough our study did not reveal significant differences in brain volumes between PTSD patients and non-PTSD patients, sample size was a major limitation and larger scale studies should be undertaken to elucidate possible neurobiological markers of PTSD in ICU survivors.https://www.frontiersin.org/article/10.3389/fnins.2020.00690/fullposttrauamtci stress disorderbrain volumecritical illnessamygdalahippocampus |
| spellingShingle | Kristina Stepanovic Kristina Stepanovic Baxter Rogers Baxter Rogers Baxter Rogers Baxter Rogers Amy L. Kiehl Amy L. Kiehl Amy L. Kiehl E. Wesley Ely E. Wesley Ely E. Wesley Ely E. Wesley Ely James Jackson James Jackson James Jackson James Jackson Jo Ellen Wilson Jo Ellen Wilson for the VISIONS Investigators and VISualizing Icu SurvivOrs Neuroradiological Sequelae Cohort Study The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study Frontiers in Neuroscience posttrauamtci stress disorder brain volume critical illness amygdala hippocampus |
| title | The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study |
| title_full | The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study |
| title_fullStr | The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study |
| title_full_unstemmed | The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study |
| title_short | The Association Between Brain Volumes and Posttraumatic Stress Disorder in Intensive Care Unit Survivors: A Preliminary Study |
| title_sort | association between brain volumes and posttraumatic stress disorder in intensive care unit survivors a preliminary study |
| topic | posttrauamtci stress disorder brain volume critical illness amygdala hippocampus |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00690/full |
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