Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there has been a concomitant increase in people living with anthracycline-induced cardiotoxicity. Accordingly, there...

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Bibliographic Details
Main Authors: Ignacio Reinal, Imelda Ontoria-Oviedo, Marta Selva, Marilù Casini, Esteban Peiró-Molina, Carlos Fambuena-Santos, Andreu M. Climent, Julia Balaguer, Adela Cañete, Jaume Mora, Ángel Raya, Pilar Sepúlveda
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Antioxidants
Subjects:
iPSC-derived cardiomyocytes
cardiotoxicity
pediatric patients
oxidative stress
doxorubicin
microRNA
Online Access:https://www.mdpi.com/2076-3921/12/7/1378

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