The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability
Purpose: to evaluate visual functions, accommodation, and local tolerance in children instilled with Phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution (Stelphrin Supra). Material and methods. 30 children (60 eyes) aged 8 to 12 (ave. 10.04 ± 0.24) with low (28 eyes) and moderate (32 e...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2022-01-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/792 |
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| author | E. P. Tarutta N. A. Tarasova S. V. Milash G. A. Markosian N. Yu. Kushnarevich T. Yu. Larina |
| author_facet | E. P. Tarutta N. A. Tarasova S. V. Milash G. A. Markosian N. Yu. Kushnarevich T. Yu. Larina |
| author_sort | E. P. Tarutta |
| collection | DOAJ |
| description | Purpose: to evaluate visual functions, accommodation, and local tolerance in children instilled with Phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution (Stelphrin Supra). Material and methods. 30 children (60 eyes) aged 8 to 12 (ave. 10.04 ± 0.24) with low (28 eyes) and moderate (32 eyes) myopia (ave. -2.96 ± 0.17 D) were tested. Refractometry, subjective and objective accommodation, optical biometry, anterior corneal surface examination, Norn test, and polling were performed prior to one-time instillation, 30 minutes after it, and after 1 month of daily bedtime instillations of Stelphrin Supra. Results. We noted a significant decrease in the tone of accommodation in the open field by 90 % from the initial value, an approximation of the nearest point of clear vision by 27 %, an increase in the volume of absolute accommodation by 57 % and the objective amplitude of accommodation by 20 %, which indicates an increase in the accommodation ability. The pupil width increased 30 minutes after a single instillation of Stelphrin Supra, which coincided with an increase in the relative accommodation reserve by 25 % from the initial one. After a month, the pupil width significantly decreased, and the positive relative accommodation reserve decreased to a level only 12 % higher than the original one. Tear film break time significantly increased by 0.89 sec, singular spot stainings disappeared in 2 out of 6 patients, lacrimation — in 6 out of 10, pain — in 1 out of 2, blurring in 4 out of 6, feeling of “sand” — in 7 out of 9 patients who had these symptoms before instillations. Conclusion. Regular instillations of Stelphrin Supra reduce the habitual tone of accommodation, increase the accommodation ability, and improve the condition of the eye surface. |
| first_indexed | 2024-04-10T02:30:54Z |
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| id | doaj.art-e16049e7d61a4c98977729ddd39a1fd1 |
| institution | Directory Open Access Journal |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| last_indexed | 2024-04-10T02:30:54Z |
| publishDate | 2022-01-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj.art-e16049e7d61a4c98977729ddd39a1fd12023-03-13T07:54:31ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602022-01-01144859410.21516/2072-0076-2021-14-4-85-94404The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerabilityE. P. Tarutta0N. A. Tarasova1S. V. Milash2G. A. Markosian3N. Yu. Kushnarevich4T. Yu. Larina5ФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииФГБУ «НМИЦ глазных болезней им. Гельмгольца» Минздрава РоссииPurpose: to evaluate visual functions, accommodation, and local tolerance in children instilled with Phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution (Stelphrin Supra). Material and methods. 30 children (60 eyes) aged 8 to 12 (ave. 10.04 ± 0.24) with low (28 eyes) and moderate (32 eyes) myopia (ave. -2.96 ± 0.17 D) were tested. Refractometry, subjective and objective accommodation, optical biometry, anterior corneal surface examination, Norn test, and polling were performed prior to one-time instillation, 30 minutes after it, and after 1 month of daily bedtime instillations of Stelphrin Supra. Results. We noted a significant decrease in the tone of accommodation in the open field by 90 % from the initial value, an approximation of the nearest point of clear vision by 27 %, an increase in the volume of absolute accommodation by 57 % and the objective amplitude of accommodation by 20 %, which indicates an increase in the accommodation ability. The pupil width increased 30 minutes after a single instillation of Stelphrin Supra, which coincided with an increase in the relative accommodation reserve by 25 % from the initial one. After a month, the pupil width significantly decreased, and the positive relative accommodation reserve decreased to a level only 12 % higher than the original one. Tear film break time significantly increased by 0.89 sec, singular spot stainings disappeared in 2 out of 6 patients, lacrimation — in 6 out of 10, pain — in 1 out of 2, blurring in 4 out of 6, feeling of “sand” — in 7 out of 9 patients who had these symptoms before instillations. Conclusion. Regular instillations of Stelphrin Supra reduce the habitual tone of accommodation, increase the accommodation ability, and improve the condition of the eye surface.https://roj.igb.ru/jour/article/view/792миопияамплитуда аккомодацииаккомодационный ответтонус аккомодациифенилэфрин |
| spellingShingle | E. P. Tarutta N. A. Tarasova S. V. Milash G. A. Markosian N. Yu. Kushnarevich T. Yu. Larina The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability Российский офтальмологический журнал миопия амплитуда аккомодации аккомодационный ответ тонус аккомодации фенилэфрин |
| title | The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| title_full | The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| title_fullStr | The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| title_full_unstemmed | The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| title_short | The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| title_sort | effect of phenylephrine hydrochloride 2 5 and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability |
| topic | миопия амплитуда аккомодации аккомодационный ответ тонус аккомодации фенилэфрин |
| url | https://roj.igb.ru/jour/article/view/792 |
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