Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

Abstract Parkinson’s disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modulator of GABAergic inhibitory transmission, and its levels are reduced in cerebros...

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Bibliographic Details
Main Authors: Chizuru Iwasawa, Naoko Kuzumaki, Yukari Suda, Reiko Kagawa, Yuko Oka, Nobutaka Hattori, Hideyuki Okano, Minoru Narita
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Brain
Subjects:
Parkinson’s disease
iPSCs
GABA
Somatostatin
Online Access:http://link.springer.com/article/10.1186/s13041-019-0426-7

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