Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola
Abstract Averrhoa carambola L. presents in its composition diversity of nutrients and vitamins. The present study aimed to extract water and fat-soluble compounds from this fruit at different stages of maturation (green and mature), perform the physical-chemical characterization as well as evaluate...
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| Format: | Article |
| Language: | English |
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Instituto Internacional de Ecologia
2023-11-01
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| Series: | Brazilian Journal of Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100899&tlng=en |
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| author | A. G. Fragoso M. M. Cadoná P. A. Bressiani E. M. V. Gomes I. A. L. Dalmolin I. B. Tonial L. T. D. Tonin P. M. V. Hirata A. P. Berti E. Düsman |
| author_facet | A. G. Fragoso M. M. Cadoná P. A. Bressiani E. M. V. Gomes I. A. L. Dalmolin I. B. Tonial L. T. D. Tonin P. M. V. Hirata A. P. Berti E. Düsman |
| author_sort | A. G. Fragoso |
| collection | DOAJ |
| description | Abstract Averrhoa carambola L. presents in its composition diversity of nutrients and vitamins. The present study aimed to extract water and fat-soluble compounds from this fruit at different stages of maturation (green and mature), perform the physical-chemical characterization as well as evaluate its cytotoxicity against hepatoma cells of Rattus norvegicus (HTC). The physicochemical results showed that the pH and molar acidity is influenced by the fruit maturation state. The fruit presented high percentage of moisture, while the percentage of total minerals (ash) increased according to its maturation stage. The results of the phytochemical screening showed that star fruits present phenolic compounds. The antioxidant activity showed greater potential for the ethanolic extracts of the green and mature star fruit. For HTC cells treated with ethanolic extract of green and mature star fruit the data show absence of cytotoxic effect. The tests with the aqueous extract showed cytotoxic/antiproliferative effect of green and mature star fruit extract, in 24, 48 and 72 hours. The presence of nutraceutical compounds and the cytotoxic/antiproliferative activity were more expressive in the aqueous extract, being an option of easily accessible solvent economic and not harmful to organisms. |
| first_indexed | 2024-03-11T12:17:08Z |
| format | Article |
| id | doaj.art-e16161db27a84a989dc347e1ade5fc9d |
| institution | Directory Open Access Journal |
| issn | 1678-4375 |
| language | English |
| last_indexed | 2024-03-11T12:17:08Z |
| publishDate | 2023-11-01 |
| publisher | Instituto Internacional de Ecologia |
| record_format | Article |
| series | Brazilian Journal of Biology |
| spelling | doaj.art-e16161db27a84a989dc347e1ade5fc9d2023-11-07T07:44:25ZengInstituto Internacional de EcologiaBrazilian Journal of Biology1678-43752023-11-018310.1590/1519-6984.276605Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambolaA. G. Fragosohttps://orcid.org/0000-0003-4433-9113M. M. Cadonáhttps://orcid.org/0009-0001-5043-9148P. A. Bressianihttps://orcid.org/0000-0001-7449-4646E. M. V. Gomeshttps://orcid.org/0000-0002-4341-0021I. A. L. Dalmolinhttps://orcid.org/0000-0003-0141-6238I. B. Tonialhttps://orcid.org/0000-0003-2600-7254L. T. D. Toninhttps://orcid.org/0000-0002-8250-8064P. M. V. Hiratahttps://orcid.org/0009-0002-4664-308XA. P. Bertihttps://orcid.org/0000-0002-8150-6569E. Düsmanhttps://orcid.org/0000-0002-4483-5638Abstract Averrhoa carambola L. presents in its composition diversity of nutrients and vitamins. The present study aimed to extract water and fat-soluble compounds from this fruit at different stages of maturation (green and mature), perform the physical-chemical characterization as well as evaluate its cytotoxicity against hepatoma cells of Rattus norvegicus (HTC). The physicochemical results showed that the pH and molar acidity is influenced by the fruit maturation state. The fruit presented high percentage of moisture, while the percentage of total minerals (ash) increased according to its maturation stage. The results of the phytochemical screening showed that star fruits present phenolic compounds. The antioxidant activity showed greater potential for the ethanolic extracts of the green and mature star fruit. For HTC cells treated with ethanolic extract of green and mature star fruit the data show absence of cytotoxic effect. The tests with the aqueous extract showed cytotoxic/antiproliferative effect of green and mature star fruit extract, in 24, 48 and 72 hours. The presence of nutraceutical compounds and the cytotoxic/antiproliferative activity were more expressive in the aqueous extract, being an option of easily accessible solvent economic and not harmful to organisms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100899&tlng=enantitumorDDPHphenolic compoundsMTTstar fruitcytotoxicity |
| spellingShingle | A. G. Fragoso M. M. Cadoná P. A. Bressiani E. M. V. Gomes I. A. L. Dalmolin I. B. Tonial L. T. D. Tonin P. M. V. Hirata A. P. Berti E. Düsman Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola Brazilian Journal of Biology antitumor DDPH phenolic compounds MTT star fruit cytotoxicity |
| title | Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola |
| title_full | Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola |
| title_fullStr | Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola |
| title_full_unstemmed | Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola |
| title_short | Cytotoxic/antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature Averrhoa carambola |
| title_sort | cytotoxic antiproliferative and nutraceutical activity of aqueous and ethanolic extracts of green and mature averrhoa carambola |
| topic | antitumor DDPH phenolic compounds MTT star fruit cytotoxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100899&tlng=en |
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