Language reorganization patterns in global aphasia–evidence from fNIRS
BackgroundExploring the brain reorganization patterns associated with language recovery would promote the treatment of global aphasia. While functional near-infrared spectroscopy (fNIRS) has been widely used in the study of speech and language impairment, its application in the field of global aphas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1025384/full |
| _version_ | 1828070493635215360 |
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| author | Haozheng Li Haozheng Li Jianju Liu Shan Tian Shunjuan Fan Tingwei Wang Hong Qian Gang Liu Gang Liu Yulian Zhu Yi Wu Yi Wu Ruiping Hu |
| author_facet | Haozheng Li Haozheng Li Jianju Liu Shan Tian Shunjuan Fan Tingwei Wang Hong Qian Gang Liu Gang Liu Yulian Zhu Yi Wu Yi Wu Ruiping Hu |
| author_sort | Haozheng Li |
| collection | DOAJ |
| description | BackgroundExploring the brain reorganization patterns associated with language recovery would promote the treatment of global aphasia. While functional near-infrared spectroscopy (fNIRS) has been widely used in the study of speech and language impairment, its application in the field of global aphasia is still limited.AimsWe aimed to identify cortical activation patterns of patients with global aphasia during naming and repetition tasks.Methods and proceduresWe recruited patients with post-stroke aphasia from the Department of Rehabilitation Medicine at Huashan Hospital. These individuals were diagnosed with global aphasia without cognitive impairments, as assessed by speech-language pathology evaluations. Age- and sex-matched healthy controls were recruited from the greater Shanghai area. During fNIRS measurement, patients and healthy controls completed the picture-naming and phrase repetition task. Cortical activation patterns on each of these language tasks were then compared between groups.Outcomes and resultsA total of nine patients with global aphasia and 14 healthy controls were included in this study. Compared with the healthy subjects, patients with global aphasia showed increased activation in the left Broca's area, middle temporal gyrus (MTG), superior temporal gyrus (STG), and pre-motor and supplementary motor cortex (SMA) (p < 0.05) in the picture-naming task. Furthermore, the latency of the oxyhemoglobin (HbO) concentration in the left supramarginal gyrus (SMG) region had a strong negative correlation with their score of the naming task (p < 0.01). In the phrase repetition task, decreased activation was detected in the left SMA and SMG (p < 0.05) of patients relative to controls.ConclusionThe left SMG plays a critical role in the language function of patients with global aphasia, especially in their abilities to name and repeat. fNIRS is a promising approach to revealing the changes in brain activities in patients with aphasia, and we believe it will contribute to a deeper understanding of the neurological mechanisms and the establishment of a novel treatment approach for global aphasia. |
| first_indexed | 2024-04-11T00:37:31Z |
| format | Article |
| id | doaj.art-e1623f63699a454b945afb45378ad8bb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T00:37:31Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-e1623f63699a454b945afb45378ad8bb2023-01-06T15:49:58ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10253841025384Language reorganization patterns in global aphasia–evidence from fNIRSHaozheng Li0Haozheng Li1Jianju Liu2Shan Tian3Shunjuan Fan4Tingwei Wang5Hong Qian6Gang Liu7Gang Liu8Yulian Zhu9Yi Wu10Yi Wu11Ruiping Hu12School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Fifth Rehabilitation Hospital, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaBackgroundExploring the brain reorganization patterns associated with language recovery would promote the treatment of global aphasia. While functional near-infrared spectroscopy (fNIRS) has been widely used in the study of speech and language impairment, its application in the field of global aphasia is still limited.AimsWe aimed to identify cortical activation patterns of patients with global aphasia during naming and repetition tasks.Methods and proceduresWe recruited patients with post-stroke aphasia from the Department of Rehabilitation Medicine at Huashan Hospital. These individuals were diagnosed with global aphasia without cognitive impairments, as assessed by speech-language pathology evaluations. Age- and sex-matched healthy controls were recruited from the greater Shanghai area. During fNIRS measurement, patients and healthy controls completed the picture-naming and phrase repetition task. Cortical activation patterns on each of these language tasks were then compared between groups.Outcomes and resultsA total of nine patients with global aphasia and 14 healthy controls were included in this study. Compared with the healthy subjects, patients with global aphasia showed increased activation in the left Broca's area, middle temporal gyrus (MTG), superior temporal gyrus (STG), and pre-motor and supplementary motor cortex (SMA) (p < 0.05) in the picture-naming task. Furthermore, the latency of the oxyhemoglobin (HbO) concentration in the left supramarginal gyrus (SMG) region had a strong negative correlation with their score of the naming task (p < 0.01). In the phrase repetition task, decreased activation was detected in the left SMA and SMG (p < 0.05) of patients relative to controls.ConclusionThe left SMG plays a critical role in the language function of patients with global aphasia, especially in their abilities to name and repeat. fNIRS is a promising approach to revealing the changes in brain activities in patients with aphasia, and we believe it will contribute to a deeper understanding of the neurological mechanisms and the establishment of a novel treatment approach for global aphasia.https://www.frontiersin.org/articles/10.3389/fneur.2022.1025384/fullglobal aphasiafNIRSpicture namingrepetition phraseleft SMG |
| spellingShingle | Haozheng Li Haozheng Li Jianju Liu Shan Tian Shunjuan Fan Tingwei Wang Hong Qian Gang Liu Gang Liu Yulian Zhu Yi Wu Yi Wu Ruiping Hu Language reorganization patterns in global aphasia–evidence from fNIRS Frontiers in Neurology global aphasia fNIRS picture naming repetition phrase left SMG |
| title | Language reorganization patterns in global aphasia–evidence from fNIRS |
| title_full | Language reorganization patterns in global aphasia–evidence from fNIRS |
| title_fullStr | Language reorganization patterns in global aphasia–evidence from fNIRS |
| title_full_unstemmed | Language reorganization patterns in global aphasia–evidence from fNIRS |
| title_short | Language reorganization patterns in global aphasia–evidence from fNIRS |
| title_sort | language reorganization patterns in global aphasia evidence from fnirs |
| topic | global aphasia fNIRS picture naming repetition phrase left SMG |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1025384/full |
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