Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow
Abstract Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and indirect antiproliferative effects of IFN-α2b have been found to occur via multiple p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-022-00415-y |
| _version_ | 1818020680477704192 |
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| author | Fei Xiong Qi Wang Guan-hua Wu Wen-zheng Liu Bing Wang Yong-jun Chen |
| author_facet | Fei Xiong Qi Wang Guan-hua Wu Wen-zheng Liu Bing Wang Yong-jun Chen |
| author_sort | Fei Xiong |
| collection | DOAJ |
| description | Abstract Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and indirect antiproliferative effects of IFN-α2b have been found to occur via multiple pathways, mainly the JAK-STAT pathway, in certain cancers. This article reviews mechanistic studies and clinical trials on IFN-α2b. Potential regulators of the function of IFN-α2b were also reviewed, which could be utilized to relieve the poor response to IFN-α2b. IFN-α2b can function not only by enhancing the systematic immune response but also by directly killing tumour cells. Different parts of JAK-STAT pathway activated by IFN-α2b, such as interferon alpha and beta receptors (IFNARs), Janus kinases (JAKs) and IFN‐stimulated gene factor 3 (ISGF3), might serve as potential target for enhancing the pharmacological action of IFN-α2b. Despite some issues that remain to be solved, based on current evidence, IFN-α2b can inhibit disease progression and improve the survival of patients with certain types of malignant tumours. More efforts should be made to address potential adverse effects and complications. |
| first_indexed | 2024-04-14T08:08:35Z |
| format | Article |
| id | doaj.art-e16267303c90457eb725154f820f5d6b |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-14T08:08:35Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-e16267303c90457eb725154f820f5d6b2022-12-22T02:04:39ZengBMCBiomarker Research2050-77712022-09-0110112310.1186/s40364-022-00415-yDirect and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrowFei Xiong0Qi Wang1Guan-hua Wu2Wen-zheng Liu3Bing Wang4Yong-jun Chen5Department of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Biliary-pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and indirect antiproliferative effects of IFN-α2b have been found to occur via multiple pathways, mainly the JAK-STAT pathway, in certain cancers. This article reviews mechanistic studies and clinical trials on IFN-α2b. Potential regulators of the function of IFN-α2b were also reviewed, which could be utilized to relieve the poor response to IFN-α2b. IFN-α2b can function not only by enhancing the systematic immune response but also by directly killing tumour cells. Different parts of JAK-STAT pathway activated by IFN-α2b, such as interferon alpha and beta receptors (IFNARs), Janus kinases (JAKs) and IFN‐stimulated gene factor 3 (ISGF3), might serve as potential target for enhancing the pharmacological action of IFN-α2b. Despite some issues that remain to be solved, based on current evidence, IFN-α2b can inhibit disease progression and improve the survival of patients with certain types of malignant tumours. More efforts should be made to address potential adverse effects and complications.https://doi.org/10.1186/s40364-022-00415-yInterferonIFN-α2bAntitumour effectsImmune responseJAK-STAT pathway |
| spellingShingle | Fei Xiong Qi Wang Guan-hua Wu Wen-zheng Liu Bing Wang Yong-jun Chen Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow Biomarker Research Interferon IFN-α2b Antitumour effects Immune response JAK-STAT pathway |
| title | Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow |
| title_full | Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow |
| title_fullStr | Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow |
| title_full_unstemmed | Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow |
| title_short | Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow |
| title_sort | direct and indirect effects of ifn α2b in malignancy treatment not only an archer but also an arrow |
| topic | Interferon IFN-α2b Antitumour effects Immune response JAK-STAT pathway |
| url | https://doi.org/10.1186/s40364-022-00415-y |
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