Epilepsy With Auditory Features: From Etiology to Treatment
Epilepsy with auditory features (EAF) is a focal epilepsy belonging to the focal epileptic syndromes with onset at variable age according to the new ILAE Classification. It is characterized by seizures with auditory aura or receptive aphasia suggesting a lateral temporal lobe involvement of the epil...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.807939/full |
| _version_ | 1818333618163941376 |
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| author | Alessandro Furia Laura Licchetta Lorenzo Muccioli Lorenzo Ferri Lorenzo Ferri Barbara Mostacci Stefania Mazzoni Veronica Menghi Raffaella Minardi Paolo Tinuper Paolo Tinuper Francesca Bisulli Francesca Bisulli |
| author_facet | Alessandro Furia Laura Licchetta Lorenzo Muccioli Lorenzo Ferri Lorenzo Ferri Barbara Mostacci Stefania Mazzoni Veronica Menghi Raffaella Minardi Paolo Tinuper Paolo Tinuper Francesca Bisulli Francesca Bisulli |
| author_sort | Alessandro Furia |
| collection | DOAJ |
| description | Epilepsy with auditory features (EAF) is a focal epilepsy belonging to the focal epileptic syndromes with onset at variable age according to the new ILAE Classification. It is characterized by seizures with auditory aura or receptive aphasia suggesting a lateral temporal lobe involvement of the epileptic discharge. Etiological factors underlying EAF are largely unknown. In the familial cases with an autosomal dominant pattern of inheritance several genes have been involved, among which the first discovered, LGI1, was thought to be predominant. However, increasing evidence now points to a multifactorial etiology, as familial and sporadic EAF share a virtually identical electro-clinical characterization and only a few have a documented genetic etiology. Patients with EAF usually have an unremarkable neurological examination and a good response to antiseizure medications. However, it must be underscored that total remission might be lower than expected and that treatment withdrawal might lead to relapses. Thus, a proper understanding of this condition is in order for better patient treatment and counseling. Further studies are still required to further characterize the many facets of EAF. |
| first_indexed | 2024-12-13T13:54:30Z |
| format | Article |
| id | doaj.art-e162d184919d4142869bd80702524543 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T13:54:30Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-e162d184919d4142869bd807025245432022-12-21T23:42:58ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-01-011210.3389/fneur.2021.807939807939Epilepsy With Auditory Features: From Etiology to TreatmentAlessandro Furia0Laura Licchetta1Lorenzo Muccioli2Lorenzo Ferri3Lorenzo Ferri4Barbara Mostacci5Stefania Mazzoni6Veronica Menghi7Raffaella Minardi8Paolo Tinuper9Paolo Tinuper10Francesca Bisulli11Francesca Bisulli12Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyDepartment of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum-University of Bologna, Bologna, ItalyIstituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, Reference Center for Rare and Complex Epilepsies, Bologna, ItalyEpilepsy with auditory features (EAF) is a focal epilepsy belonging to the focal epileptic syndromes with onset at variable age according to the new ILAE Classification. It is characterized by seizures with auditory aura or receptive aphasia suggesting a lateral temporal lobe involvement of the epileptic discharge. Etiological factors underlying EAF are largely unknown. In the familial cases with an autosomal dominant pattern of inheritance several genes have been involved, among which the first discovered, LGI1, was thought to be predominant. However, increasing evidence now points to a multifactorial etiology, as familial and sporadic EAF share a virtually identical electro-clinical characterization and only a few have a documented genetic etiology. Patients with EAF usually have an unremarkable neurological examination and a good response to antiseizure medications. However, it must be underscored that total remission might be lower than expected and that treatment withdrawal might lead to relapses. Thus, a proper understanding of this condition is in order for better patient treatment and counseling. Further studies are still required to further characterize the many facets of EAF.https://www.frontiersin.org/articles/10.3389/fneur.2021.807939/fullauditory hallucinationsepilepsyDEPDC5mTORLGI1aphasic seizures |
| spellingShingle | Alessandro Furia Laura Licchetta Lorenzo Muccioli Lorenzo Ferri Lorenzo Ferri Barbara Mostacci Stefania Mazzoni Veronica Menghi Raffaella Minardi Paolo Tinuper Paolo Tinuper Francesca Bisulli Francesca Bisulli Epilepsy With Auditory Features: From Etiology to Treatment Frontiers in Neurology auditory hallucinations epilepsy DEPDC5 mTOR LGI1 aphasic seizures |
| title | Epilepsy With Auditory Features: From Etiology to Treatment |
| title_full | Epilepsy With Auditory Features: From Etiology to Treatment |
| title_fullStr | Epilepsy With Auditory Features: From Etiology to Treatment |
| title_full_unstemmed | Epilepsy With Auditory Features: From Etiology to Treatment |
| title_short | Epilepsy With Auditory Features: From Etiology to Treatment |
| title_sort | epilepsy with auditory features from etiology to treatment |
| topic | auditory hallucinations epilepsy DEPDC5 mTOR LGI1 aphasic seizures |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.807939/full |
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