Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma
Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation of glaucoma. Despite being in the focus of the studies for decades, the characteristic and the exact pathology of ne...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/5/671 |
| _version_ | 1797536346570489856 |
|---|---|
| author | Yuan Feng Verena Prokosch Hanhan Liu |
| author_facet | Yuan Feng Verena Prokosch Hanhan Liu |
| author_sort | Yuan Feng |
| collection | DOAJ |
| description | Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation of glaucoma. Despite being in the focus of the studies for decades, the characteristic and the exact pathology of neurodegeneration in glaucoma remains unclear. Oxidative stress is believed to be one of the main risk factors in neurodegeneration, especially its damage to the retinal ganglion cells. Hydrogen sulfide (H<sub>2</sub>S), the recently recognized gas signaling molecule, plays a pivotal role in the nervous system, vascular system, and immune system. It has also shown properties in regulating oxidative stress through different pathways in vivo. In this review, we summarize the distribution and the properties of H<sub>2</sub>S within the eye with an emphasis on its role in modulating oxidative stress in glaucoma. |
| first_indexed | 2024-03-10T11:58:24Z |
| format | Article |
| id | doaj.art-e163ce1ae5df4dd6a7a957c5efe49edd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T11:58:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e163ce1ae5df4dd6a7a957c5efe49edd2023-11-21T17:10:32ZengMDPI AGAntioxidants2076-39212021-04-0110567110.3390/antiox10050671Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in GlaucomaYuan Feng0Verena Prokosch1Hanhan Liu2Department of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyGlaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons. Elevated intraocular pressure (IOP) is the main clinical manifestation of glaucoma. Despite being in the focus of the studies for decades, the characteristic and the exact pathology of neurodegeneration in glaucoma remains unclear. Oxidative stress is believed to be one of the main risk factors in neurodegeneration, especially its damage to the retinal ganglion cells. Hydrogen sulfide (H<sub>2</sub>S), the recently recognized gas signaling molecule, plays a pivotal role in the nervous system, vascular system, and immune system. It has also shown properties in regulating oxidative stress through different pathways in vivo. In this review, we summarize the distribution and the properties of H<sub>2</sub>S within the eye with an emphasis on its role in modulating oxidative stress in glaucoma.https://www.mdpi.com/2076-3921/10/5/671hydrogen sulfideoxidative stressglaucomaneurodegeneration |
| spellingShingle | Yuan Feng Verena Prokosch Hanhan Liu Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma Antioxidants hydrogen sulfide oxidative stress glaucoma neurodegeneration |
| title | Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma |
| title_full | Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma |
| title_fullStr | Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma |
| title_full_unstemmed | Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma |
| title_short | Current Perspective of Hydrogen Sulfide as a Novel Gaseous Modulator of Oxidative Stress in Glaucoma |
| title_sort | current perspective of hydrogen sulfide as a novel gaseous modulator of oxidative stress in glaucoma |
| topic | hydrogen sulfide oxidative stress glaucoma neurodegeneration |
| url | https://www.mdpi.com/2076-3921/10/5/671 |
| work_keys_str_mv | AT yuanfeng currentperspectiveofhydrogensulfideasanovelgaseousmodulatorofoxidativestressinglaucoma AT verenaprokosch currentperspectiveofhydrogensulfideasanovelgaseousmodulatorofoxidativestressinglaucoma AT hanhanliu currentperspectiveofhydrogensulfideasanovelgaseousmodulatorofoxidativestressinglaucoma |