Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma
Pathological examination by endoscopic ultrasound–fine needle aspiration is not possible in approximately 10% of pancreatic tumor cases. Pancreatic juice cytology (PJC) is considered an alternative diagnostic method. However, its diagnostic capability is insufficient, and PJC has been repeatedly red...
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MDPI AG
2023-04-01
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author | Yohei Takeda Kazuya Matsumoto Takumi Onoyama Taro Yamashita Hiroki Koda Wataru Hamamoto Yuri Sakamoto Takuya Shimosaka Shiho Kawahara Yuta Seki Hiroki Kurumi Yasushi Horie Hajime Isomoto Naoyuki Yamaguchi |
author_facet | Yohei Takeda Kazuya Matsumoto Takumi Onoyama Taro Yamashita Hiroki Koda Wataru Hamamoto Yuri Sakamoto Takuya Shimosaka Shiho Kawahara Yuta Seki Hiroki Kurumi Yasushi Horie Hajime Isomoto Naoyuki Yamaguchi |
author_sort | Yohei Takeda |
collection | DOAJ |
description | Pathological examination by endoscopic ultrasound–fine needle aspiration is not possible in approximately 10% of pancreatic tumor cases. Pancreatic juice cytology (PJC) is considered an alternative diagnostic method. However, its diagnostic capability is insufficient, and PJC has been repeatedly redevised. Serial pancreatic juice aspiration cytological examination (SPACE) and secretin-loaded PJC (S-PJC) have been recently introduced as alternative diagnostic methods. This study aimed to determine the diagnostic capacity and safety of SPACE and S-PJC using a propensity score-matched analysis. The sensitivity, specificity, and accuracy were 75.0%, 100%, and 92.3% for S-PJC, respectively, and 71.4%, 100%, and 92.3% for SPACE, respectively, meaning that there was no significant difference between the groups. Four patients (15.4%) each in the S-PJC and SPACE groups experienced complications, including postendoscopic retrograde cholangiopancreatography, pancreatitis, and cholangitis. Overall, there was no difference in efficacy and safety between the SPACE and S-PJC groups. |
first_indexed | 2024-03-11T04:21:38Z |
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id | doaj.art-e16598b69acb4d3aa24930d20c0150aa |
institution | Directory Open Access Journal |
issn | 2075-4418 |
language | English |
last_indexed | 2024-03-11T04:21:38Z |
publishDate | 2023-04-01 |
publisher | MDPI AG |
record_format | Article |
series | Diagnostics |
spelling | doaj.art-e16598b69acb4d3aa24930d20c0150aa2023-11-17T22:45:01ZengMDPI AGDiagnostics2075-44182023-04-01139153610.3390/diagnostics13091536Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal AdenocarcinomaYohei Takeda0Kazuya Matsumoto1Takumi Onoyama2Taro Yamashita3Hiroki Koda4Wataru Hamamoto5Yuri Sakamoto6Takuya Shimosaka7Shiho Kawahara8Yuta Seki9Hiroki Kurumi10Yasushi Horie11Hajime Isomoto12Naoyuki Yamaguchi13Division of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDivision of Organ Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Tottori 683-8504, JapanDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, JapanDepartment of Gastroenterology and Hepatology, Graduate School of Biological Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanPathological examination by endoscopic ultrasound–fine needle aspiration is not possible in approximately 10% of pancreatic tumor cases. Pancreatic juice cytology (PJC) is considered an alternative diagnostic method. However, its diagnostic capability is insufficient, and PJC has been repeatedly redevised. Serial pancreatic juice aspiration cytological examination (SPACE) and secretin-loaded PJC (S-PJC) have been recently introduced as alternative diagnostic methods. This study aimed to determine the diagnostic capacity and safety of SPACE and S-PJC using a propensity score-matched analysis. The sensitivity, specificity, and accuracy were 75.0%, 100%, and 92.3% for S-PJC, respectively, and 71.4%, 100%, and 92.3% for SPACE, respectively, meaning that there was no significant difference between the groups. Four patients (15.4%) each in the S-PJC and SPACE groups experienced complications, including postendoscopic retrograde cholangiopancreatography, pancreatitis, and cholangitis. Overall, there was no difference in efficacy and safety between the SPACE and S-PJC groups.https://www.mdpi.com/2075-4418/13/9/1536pancreatic ductal adenocarcinomapancreatic juice cytologysynthetic secretinserial pancreatic juice aspiration cytological examination |
spellingShingle | Yohei Takeda Kazuya Matsumoto Takumi Onoyama Taro Yamashita Hiroki Koda Wataru Hamamoto Yuri Sakamoto Takuya Shimosaka Shiho Kawahara Yuta Seki Hiroki Kurumi Yasushi Horie Hajime Isomoto Naoyuki Yamaguchi Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma Diagnostics pancreatic ductal adenocarcinoma pancreatic juice cytology synthetic secretin serial pancreatic juice aspiration cytological examination |
title | Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma |
title_full | Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma |
title_fullStr | Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma |
title_full_unstemmed | Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma |
title_short | Pancreatic Juice Cytology Evaluations Using Synthetic Secretin and Serial Pancreatic Juice Aspiration Cytological Examination for the Diagnosis of Pancreatic Ductal Adenocarcinoma |
title_sort | pancreatic juice cytology evaluations using synthetic secretin and serial pancreatic juice aspiration cytological examination for the diagnosis of pancreatic ductal adenocarcinoma |
topic | pancreatic ductal adenocarcinoma pancreatic juice cytology synthetic secretin serial pancreatic juice aspiration cytological examination |
url | https://www.mdpi.com/2075-4418/13/9/1536 |
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