The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia

The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia

Cardioplegic cardioprotection strategies used during paediatric open-heart surgery remain suboptimal. Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, has been shown to be cardioprotective against ischemia/reperfusion injury in a variety of experimental models and this study therefore tested the...

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Bibliographic Details
Main Authors: Katie L. Skeffington, Eltayeb Mohamed Ahmed, Filippo Rapetto, Guillaume Chanoit, Andrew R. Bond, Antonella Vardeu, Mohamed T. Ghorbel, M-Saadeh Suleiman, Massimo Caputo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac surgery
cardioprotection
ischaemia and reperfusion injury
congenital heart disease
sildenafil
cardiopulmonary bypass
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194645/full

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