Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects
Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02831/full |
| _version_ | 1828471634562908160 |
|---|---|
| author | Mine Özcan-Wahlbrink Mine Özcan-Wahlbrink Christoph Schifflers Christoph Schifflers Christoph Schifflers Angelika B. Riemer Angelika B. Riemer |
| author_facet | Mine Özcan-Wahlbrink Mine Özcan-Wahlbrink Christoph Schifflers Christoph Schifflers Christoph Schifflers Angelika B. Riemer Angelika B. Riemer |
| author_sort | Mine Özcan-Wahlbrink |
| collection | DOAJ |
| description | Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy. |
| first_indexed | 2024-12-11T05:15:58Z |
| format | Article |
| id | doaj.art-e16932090e6541209ddfc88e0cb18b7c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T05:15:58Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e16932090e6541209ddfc88e0cb18b7c2022-12-22T01:19:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02831490443Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological AspectsMine Özcan-Wahlbrink0Mine Özcan-Wahlbrink1Christoph Schifflers2Christoph Schifflers3Christoph Schifflers4Angelika B. Riemer5Angelika B. Riemer6Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, GermanyMolecular Vaccine Design, German Center for Infection Research, Partner Site Heidelberg, Heidelberg, GermanyImmunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, GermanyMolecular Vaccine Design, German Center for Infection Research, Partner Site Heidelberg, Heidelberg, GermanyCell Biology Research Unit (URBC)—Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, BelgiumImmunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, GermanyMolecular Vaccine Design, German Center for Infection Research, Partner Site Heidelberg, Heidelberg, GermanyHead and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human papillomavirus (HPV). Depending on the involvement of HPV, HNSCC follow different pathways of carcinogenesis and show distinct clinical presentations regarding survival, prognosis and treatment response. For instance, HPV-driven HNSCC exhibit an enhanced radiation response compared to their typically radioresistant HPV-negative counterparts. Although radiosensitivity of HNSCC has been studied by many research groups, the major causes for the difference in radiation responses between HPV-driven and HPV-negative HNSCC are still an open question. In this mini review, we discuss the reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven HNSCC, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.https://www.frontiersin.org/article/10.3389/fimmu.2019.02831/fullhuman papillomavirus (HPV)head and neck squamous cell carcinoma (HNSCC)HPV-driven HNSCCoropharyngeal squamous cell carcinoma (OPSCC)radiation sensitivityimmune response |
| spellingShingle | Mine Özcan-Wahlbrink Mine Özcan-Wahlbrink Christoph Schifflers Christoph Schifflers Christoph Schifflers Angelika B. Riemer Angelika B. Riemer Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects Frontiers in Immunology human papillomavirus (HPV) head and neck squamous cell carcinoma (HNSCC) HPV-driven HNSCC oropharyngeal squamous cell carcinoma (OPSCC) radiation sensitivity immune response |
| title | Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects |
| title_full | Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects |
| title_fullStr | Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects |
| title_full_unstemmed | Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects |
| title_short | Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects |
| title_sort | enhanced radiation sensitivity of human papillomavirus driven head and neck cancer focus on immunological aspects |
| topic | human papillomavirus (HPV) head and neck squamous cell carcinoma (HNSCC) HPV-driven HNSCC oropharyngeal squamous cell carcinoma (OPSCC) radiation sensitivity immune response |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02831/full |
| work_keys_str_mv | AT mineozcanwahlbrink enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT mineozcanwahlbrink enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT christophschifflers enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT christophschifflers enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT christophschifflers enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT angelikabriemer enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects AT angelikabriemer enhancedradiationsensitivityofhumanpapillomavirusdrivenheadandneckcancerfocusonimmunologicalaspects |