Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis
Background: Recent interests have mainly focused on the roles of serum calcium and phosphorus and their product (Ca-P product) in the development of valvular heart disease. The present study assessed the relationship between the Ca-P product and the severity of valvular heart disease in end-stage re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-04-01
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| Series: | Journal of Tehran University Heart Center |
| Subjects: | |
| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/166 |
| _version_ | 1818835665626857472 |
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| author | Masoumeh Kahnooji Mohammad Masoomi Ali Naderinasab Akram Zaeem Mehrdad Sheikhvatan |
| author_facet | Masoumeh Kahnooji Mohammad Masoomi Ali Naderinasab Akram Zaeem Mehrdad Sheikhvatan |
| author_sort | Masoumeh Kahnooji |
| collection | DOAJ |
| description | Background: Recent interests have mainly focused on the roles of serum calcium and phosphorus and their product (Ca-P product) in the development of valvular heart disease. The present study assessed the relationship between the Ca-P product and the severity of valvular heart disease in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis.
Methods: This cross-sectional study reviewed the clinical course of 72 consecutive patients with the final diagnosis of ESRD candidated for chronic hemodialysis. The severity of valvular heart disease was determined using M-mode two-dimensional echocardiography. The serum calcium and phosphate values adopted were those values measured on the day between the two consecutive dialyses, and the Ca-P product was calculated.
Results: The most common causes of ESRD were diabetic nephropathy, malignant hypertension, and chronic glomerulonephritis. The mean Ca-P product level in the dialysis patients was 50.44 ± 17.78 mg2/dL2. The receiver-operator characteristic (ROC) curve illustrated that a Ca-P product level > 42 mg2/dL2 was the optimal value in terms of sensitivity and specificity for predicting the presence of valvular insufficiency. Aortic insufficiency was directly associated with a high Ca-P product value after adjustment for age, gender, serum albumin, diabetes, hypertension, hyperlipidemia, coronary artery disease, and serum creatinine (β = 0.412, SE = 158, p value= 0.011).
Conclusion: A positive relationship between the Ca-P product value and the severity of aortic insufficiency is expected. Achieving an appropriate control of the Ca-P product level may decrease aortic valve calcification and improve the survival of patients on chronic hemodialysis. |
| first_indexed | 2024-12-19T02:54:20Z |
| format | Article |
| id | doaj.art-e169a2f2ee7e468a811922655ec4de1e |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-12-19T02:54:20Z |
| publishDate | 2010-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-e169a2f2ee7e468a811922655ec4de1e2022-12-21T20:38:27ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712010-04-0152164Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic HemodialysisMasoumeh Kahnooji0Mohammad Masoomi1Ali Naderinasab2Akram Zaeem3Mehrdad Sheikhvatan4Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Background: Recent interests have mainly focused on the roles of serum calcium and phosphorus and their product (Ca-P product) in the development of valvular heart disease. The present study assessed the relationship between the Ca-P product and the severity of valvular heart disease in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis. Methods: This cross-sectional study reviewed the clinical course of 72 consecutive patients with the final diagnosis of ESRD candidated for chronic hemodialysis. The severity of valvular heart disease was determined using M-mode two-dimensional echocardiography. The serum calcium and phosphate values adopted were those values measured on the day between the two consecutive dialyses, and the Ca-P product was calculated. Results: The most common causes of ESRD were diabetic nephropathy, malignant hypertension, and chronic glomerulonephritis. The mean Ca-P product level in the dialysis patients was 50.44 ± 17.78 mg2/dL2. The receiver-operator characteristic (ROC) curve illustrated that a Ca-P product level > 42 mg2/dL2 was the optimal value in terms of sensitivity and specificity for predicting the presence of valvular insufficiency. Aortic insufficiency was directly associated with a high Ca-P product value after adjustment for age, gender, serum albumin, diabetes, hypertension, hyperlipidemia, coronary artery disease, and serum creatinine (β = 0.412, SE = 158, p value= 0.011). Conclusion: A positive relationship between the Ca-P product value and the severity of aortic insufficiency is expected. Achieving an appropriate control of the Ca-P product level may decrease aortic valve calcification and improve the survival of patients on chronic hemodialysis.https://jthc.tums.ac.ir/index.php/jthc/article/view/166Heart valve diseaseRenal dialysisKidney failureCalciumPhosphorus |
| spellingShingle | Masoumeh Kahnooji Mohammad Masoomi Ali Naderinasab Akram Zaeem Mehrdad Sheikhvatan Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis Journal of Tehran University Heart Center Heart valve disease Renal dialysis Kidney failure Calcium Phosphorus |
| title | Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis |
| title_full | Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis |
| title_fullStr | Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis |
| title_full_unstemmed | Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis |
| title_short | Relationship between Calcium-Phosphorus Product and Severity of Valvular Heart Insufficiency in Patients Undergoing Chronic Hemodialysis |
| title_sort | relationship between calcium phosphorus product and severity of valvular heart insufficiency in patients undergoing chronic hemodialysis |
| topic | Heart valve disease Renal dialysis Kidney failure Calcium Phosphorus |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/166 |
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