Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study
Introduction: Coronavirus Disease-2019 (COVID-19) pandemic unprecedentely led to health crisis in population across the globe. Even though the advent of vaccine has brought the spread of infection under control, shortage in vaccine supply, surge in breakthrough infections and associated mucormycosis...
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JCDR Research and Publications Private Limited
2022-03-01
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Online Access: | https://www.jcdr.net/articles/PDF/16114/53675_CE[Ra1]_F(KR)_PF1(AG_SS)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdf |
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author | Kasturi Kshitija Teeda Lakshmi Sri Naga Poojitha Ande Dimple Sree Mounika Deepak Rosha |
author_facet | Kasturi Kshitija Teeda Lakshmi Sri Naga Poojitha Ande Dimple Sree Mounika Deepak Rosha |
author_sort | Kasturi Kshitija |
collection | DOAJ |
description | Introduction: Coronavirus Disease-2019 (COVID-19) pandemic unprecedentely led to health crisis in population across the globe. Even though the advent of vaccine has brought the spread of infection under control, shortage in vaccine supply, surge in breakthrough infections and associated mucormycosis in immunosuppressed individuals posed a potential threat.
Aim: To know the incidence and outcome of COVID-19 with superadded mucormycosis in vaccinated and unvaccinated people.
Materials and Methods: The present cross-sectional study undertaken for a period of four months. April to July 2021 in the Department of Respiratory Medicine at Tertiary Care Hospital, New Delhi, India. Hospitalised COVID-19 patients were enrolled in the study. Details of age, gender and co-morbidities were taken into account. In COVID-19 with mucormycosis, glycosylated haemoglobin value and steroid therapy were also noted. Clinical outcome for all the cases were analysed. Statistical analysis of the data collected was done with Statistical Package for the Social Sciences (SPSS) version 20.0 software.
Results: Out of 134 cases, 84 and 50 cases belonged to vaccinated and unvaccinated groups respectively. Isolated COVID-19 infection was noted in 102 cases and COVID-19 with mucormycosis in 32 cases. Diabetes mellitus and steroid therapy showed to be the predisposing factors for development of mucormycosis in COVID-19 cases. High proportion of unvaccinated individuals died due to isolated COVID-19 infection compared to vaccinated individuals and it was found to be statistically significant.
Conclusion: To combat serious threats caused by the COVID-19 pandemic, complete vaccination which offers maximum protection is mandatory. |
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language | English |
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spelling | doaj.art-e16b51976f3c4060977df4f05ea5c5112023-02-06T09:10:11ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-03-01163EC19EC2210.7860/JCDR/2022/53675.16114Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional StudyKasturi Kshitija0Teeda Lakshmi Sri Naga Poojitha1Ande Dimple Sree Mounika2Deepak Rosha3Associate Professor, Department of Pathology, Bhaskar Medical College and Bhaskar General Hospital, KNR University, Hyderabad, Telangana, India.Junior Resident, Department of Respiratory Medicine, Indraprastha Apollo Hospital, New Delhi, India.MBBS Student, Bhaskar Medical College and Bhaskar General Hospital, KNR University, Hyderabad, Telangana, India.Senior Consultant, Department of Respiratory Medicine, Critical Care and Sleep Medicine, Indraprastha Apollo Hospital, New Delhi, India.Introduction: Coronavirus Disease-2019 (COVID-19) pandemic unprecedentely led to health crisis in population across the globe. Even though the advent of vaccine has brought the spread of infection under control, shortage in vaccine supply, surge in breakthrough infections and associated mucormycosis in immunosuppressed individuals posed a potential threat. Aim: To know the incidence and outcome of COVID-19 with superadded mucormycosis in vaccinated and unvaccinated people. Materials and Methods: The present cross-sectional study undertaken for a period of four months. April to July 2021 in the Department of Respiratory Medicine at Tertiary Care Hospital, New Delhi, India. Hospitalised COVID-19 patients were enrolled in the study. Details of age, gender and co-morbidities were taken into account. In COVID-19 with mucormycosis, glycosylated haemoglobin value and steroid therapy were also noted. Clinical outcome for all the cases were analysed. Statistical analysis of the data collected was done with Statistical Package for the Social Sciences (SPSS) version 20.0 software. Results: Out of 134 cases, 84 and 50 cases belonged to vaccinated and unvaccinated groups respectively. Isolated COVID-19 infection was noted in 102 cases and COVID-19 with mucormycosis in 32 cases. Diabetes mellitus and steroid therapy showed to be the predisposing factors for development of mucormycosis in COVID-19 cases. High proportion of unvaccinated individuals died due to isolated COVID-19 infection compared to vaccinated individuals and it was found to be statistically significant. Conclusion: To combat serious threats caused by the COVID-19 pandemic, complete vaccination which offers maximum protection is mandatory.https://www.jcdr.net/articles/PDF/16114/53675_CE[Ra1]_F(KR)_PF1(AG_SS)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdfcoronavirus disease-2019outcomesuperadded infectionvaccination |
spellingShingle | Kasturi Kshitija Teeda Lakshmi Sri Naga Poojitha Ande Dimple Sree Mounika Deepak Rosha Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study Journal of Clinical and Diagnostic Research coronavirus disease-2019 outcome superadded infection vaccination |
title | Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study |
title_full | Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study |
title_fullStr | Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study |
title_full_unstemmed | Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study |
title_short | Analysis of COVID-19 and Mucormycosis Infection in Vaccinated and Unvaccinated Individuals: A Cross-sectional Study |
title_sort | analysis of covid 19 and mucormycosis infection in vaccinated and unvaccinated individuals a cross sectional study |
topic | coronavirus disease-2019 outcome superadded infection vaccination |
url | https://www.jcdr.net/articles/PDF/16114/53675_CE[Ra1]_F(KR)_PF1(AG_SS)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdf |
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