Shining a Light on Colibactin Biology
Colibactin is a secondary metabolite encoded by the <i>pks</i> gene island identified in several Enterobacteriaceae, including some pathogenic <i>Escherichia coli</i> (<i>E. coli</i>) commonly enriched in mucosal tissue collected from patients with inflammatory bo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/5/346 |
| _version_ | 1797534557032939520 |
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| author | Michael W. Dougherty Christian Jobin |
| author_facet | Michael W. Dougherty Christian Jobin |
| author_sort | Michael W. Dougherty |
| collection | DOAJ |
| description | Colibactin is a secondary metabolite encoded by the <i>pks</i> gene island identified in several Enterobacteriaceae, including some pathogenic <i>Escherichia coli</i> (<i>E. coli</i>) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease and colorectal cancer. <i>E. coli</i> harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental knowledge regarding colibactin function is lacking. To accurately assess the role of <i>pks</i><sup>+</sup> <i>E. coli</i> in cancer etiology, the biological mechanisms governing production and delivery of colibactin by these bacteria must be elucidated. In this review, we will focus on recent advances in our understanding of colibactin’s structural mode-of-action and mutagenic potential with consideration for how this activity may be regulated by physiologic conditions within the intestine. |
| first_indexed | 2024-03-10T11:31:09Z |
| format | Article |
| id | doaj.art-e16bdd1099264d0a863dd2b871091c28 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T11:31:09Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e16bdd1099264d0a863dd2b871091c282023-11-21T19:16:23ZengMDPI AGToxins2072-66512021-05-0113534610.3390/toxins13050346Shining a Light on Colibactin BiologyMichael W. Dougherty0Christian Jobin1Department of Medicine, University of Florida, Gainesville, FL 32610, USADepartment of Medicine, University of Florida, Gainesville, FL 32610, USAColibactin is a secondary metabolite encoded by the <i>pks</i> gene island identified in several Enterobacteriaceae, including some pathogenic <i>Escherichia coli</i> (<i>E. coli</i>) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease and colorectal cancer. <i>E. coli</i> harboring this biosynthetic gene cluster cause DNA damage and tumorigenesis in cell lines and pre-clinical models, yet fundamental knowledge regarding colibactin function is lacking. To accurately assess the role of <i>pks</i><sup>+</sup> <i>E. coli</i> in cancer etiology, the biological mechanisms governing production and delivery of colibactin by these bacteria must be elucidated. In this review, we will focus on recent advances in our understanding of colibactin’s structural mode-of-action and mutagenic potential with consideration for how this activity may be regulated by physiologic conditions within the intestine.https://www.mdpi.com/2072-6651/13/5/346colibactingenotoxin<i>pks</i><i>Escherichia coli</i>colorectal cancerDNA damage |
| spellingShingle | Michael W. Dougherty Christian Jobin Shining a Light on Colibactin Biology Toxins colibactin genotoxin <i>pks</i> <i>Escherichia coli</i> colorectal cancer DNA damage |
| title | Shining a Light on Colibactin Biology |
| title_full | Shining a Light on Colibactin Biology |
| title_fullStr | Shining a Light on Colibactin Biology |
| title_full_unstemmed | Shining a Light on Colibactin Biology |
| title_short | Shining a Light on Colibactin Biology |
| title_sort | shining a light on colibactin biology |
| topic | colibactin genotoxin <i>pks</i> <i>Escherichia coli</i> colorectal cancer DNA damage |
| url | https://www.mdpi.com/2072-6651/13/5/346 |
| work_keys_str_mv | AT michaelwdougherty shiningalightoncolibactinbiology AT christianjobin shiningalightoncolibactinbiology |