Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence

Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence

ABSTRACTMycobacterium abscessus pulmonary disease is increasing in prevalence globally, particularly for individuals with cystic fibrosis. These infections are challenging to treat due to a high rate of resistance. Amikacin is critical to treatment, but the development of toxicity, amikacin resistan...

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Bibliographic Details
Main Authors: Joy E. Gibson, Nishant Nandanwar, Michael N. Neely
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:Microbiology Spectrum
Subjects:
amikacin
aminoglycosides
Mycobacterium abscessus
NTM
pharmacokinetics
pharmacodynamics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03222-23

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