Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition
Protein ubiquitination plays indispensable roles in the regulation of cell homeostasis and pathogenesis of neoplastic, infectious, and neurodegenerative diseases. Given the importance of this modification, it is to be expected that several pathogenic bacteria have developed the ability to utilize th...
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MDPI AG
2014-08-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/3/3/848 |
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| author | Minsoo Kim Ryota Otsubo Hanako Morikawa Akira Nishide Kenji Takagi Chihiro Sasakawa Tsunehiro Mizushima |
| author_facet | Minsoo Kim Ryota Otsubo Hanako Morikawa Akira Nishide Kenji Takagi Chihiro Sasakawa Tsunehiro Mizushima |
| author_sort | Minsoo Kim |
| collection | DOAJ |
| description | Protein ubiquitination plays indispensable roles in the regulation of cell homeostasis and pathogenesis of neoplastic, infectious, and neurodegenerative diseases. Given the importance of this modification, it is to be expected that several pathogenic bacteria have developed the ability to utilize the host ubiquitin system for their own benefit. Modulation of the host ubiquitin system by bacterial effector proteins inhibits innate immune responses and hijacks central signaling pathways. Bacterial effectors mimic enzymes of the host ubiquitin system, but may or may not be structurally similar to the mammalian enzymes. Other effectors bind and modify components of the host ubiquitin system, and some are themselves subject to ubiquitination. This review will describe recent findings, based on structural analyses, regarding how pathogens use post-translational modifications of proteins to establish an infection. |
| first_indexed | 2024-03-12T08:20:11Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:20:11Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj.art-e16bf752e1904d2ca8b0741963b069882023-09-02T18:34:36ZengMDPI AGCells2073-44092014-08-013384886410.3390/cells3030848cells3030848Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate RecognitionMinsoo Kim0Ryota Otsubo1Hanako Morikawa2Akira Nishide3Kenji Takagi4Chihiro Sasakawa5Tsunehiro Mizushima6Division of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku 4-6-1, Tokyo 108-8639, JapanDivision of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku 4-6-1, Tokyo 108-8639, JapanDivision of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku 4-6-1, Tokyo 108-8639, JapanPicobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, JapanPicobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, JapanDivision of Bacterial Infection Biology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku 4-6-1, Tokyo 108-8639, JapanPicobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, 3-2-1, Kouto, Kamigori-cho, Ako-gun, Hyogo 678-1297, JapanProtein ubiquitination plays indispensable roles in the regulation of cell homeostasis and pathogenesis of neoplastic, infectious, and neurodegenerative diseases. Given the importance of this modification, it is to be expected that several pathogenic bacteria have developed the ability to utilize the host ubiquitin system for their own benefit. Modulation of the host ubiquitin system by bacterial effector proteins inhibits innate immune responses and hijacks central signaling pathways. Bacterial effectors mimic enzymes of the host ubiquitin system, but may or may not be structurally similar to the mammalian enzymes. Other effectors bind and modify components of the host ubiquitin system, and some are themselves subject to ubiquitination. This review will describe recent findings, based on structural analyses, regarding how pathogens use post-translational modifications of proteins to establish an infection.http://www.mdpi.com/2073-4409/3/3/848ubiquitineffectorstructurepathogenic bacteria |
| spellingShingle | Minsoo Kim Ryota Otsubo Hanako Morikawa Akira Nishide Kenji Takagi Chihiro Sasakawa Tsunehiro Mizushima Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition Cells ubiquitin effector structure pathogenic bacteria |
| title | Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition |
| title_full | Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition |
| title_fullStr | Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition |
| title_full_unstemmed | Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition |
| title_short | Bacterial Effectors and Their Functions in the Ubiquitin-Proteasome System: Insight from the Modes of Substrate Recognition |
| title_sort | bacterial effectors and their functions in the ubiquitin proteasome system insight from the modes of substrate recognition |
| topic | ubiquitin effector structure pathogenic bacteria |
| url | http://www.mdpi.com/2073-4409/3/3/848 |
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