Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
Abstract Background Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. Case presentation A 77-year-old healthy Sri Lankan man presented to the T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-021-03135-3 |
| _version_ | 1818363130588168192 |
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| author | Manana Dewage Sankani Vishvara Kularathna Senanayake Abeysinghe Mudiyanselage Kularatne Manoji Pathirage Pala Thanthirige Madhushi Anuradha Nanayakkara |
| author_facet | Manana Dewage Sankani Vishvara Kularathna Senanayake Abeysinghe Mudiyanselage Kularatne Manoji Pathirage Pala Thanthirige Madhushi Anuradha Nanayakkara |
| author_sort | Manana Dewage Sankani Vishvara Kularathna |
| collection | DOAJ |
| description | Abstract Background Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. Case presentation A 77-year-old healthy Sri Lankan man presented to the Teaching Hospital Peradeniya with severe leptospirosis complicated with acute kidney injury, pulmonary hemorrhages, myocarditis, and severe thrombocytopenia. He was deteriorating despite treatment with intravenous antibiotics and methylprednisolone boluses. He made a dramatic improvement with two cycles of plasma exchange. Conclusion Therapeutic plasma exchange is a life-saving treatment modality in severe leptospirosis with multiorgan failure. |
| first_indexed | 2024-12-13T21:43:35Z |
| format | Article |
| id | doaj.art-e16cb549c89a4a859efc89c59a7beba1 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-13T21:43:35Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-e16cb549c89a4a859efc89c59a7beba12022-12-21T23:30:29ZengBMCJournal of Medical Case Reports1752-19472021-12-011511610.1186/s13256-021-03135-3Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case reportManana Dewage Sankani Vishvara Kularathna0Senanayake Abeysinghe Mudiyanselage Kularatne1Manoji Pathirage2Pala Thanthirige Madhushi Anuradha Nanayakkara3Teaching Hospital PeradeniyaTeaching Hospital PeradeniyaTeaching Hospital PeradeniyaTeaching Hospital PeradeniyaAbstract Background Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. Case presentation A 77-year-old healthy Sri Lankan man presented to the Teaching Hospital Peradeniya with severe leptospirosis complicated with acute kidney injury, pulmonary hemorrhages, myocarditis, and severe thrombocytopenia. He was deteriorating despite treatment with intravenous antibiotics and methylprednisolone boluses. He made a dramatic improvement with two cycles of plasma exchange. Conclusion Therapeutic plasma exchange is a life-saving treatment modality in severe leptospirosis with multiorgan failure.https://doi.org/10.1186/s13256-021-03135-3LeptospirosisZoonotic infectionPulmonary hemorrhagesMyocarditisMultiple organ failurePlasma exchange |
| spellingShingle | Manana Dewage Sankani Vishvara Kularathna Senanayake Abeysinghe Mudiyanselage Kularatne Manoji Pathirage Pala Thanthirige Madhushi Anuradha Nanayakkara Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report Journal of Medical Case Reports Leptospirosis Zoonotic infection Pulmonary hemorrhages Myocarditis Multiple organ failure Plasma exchange |
| title | Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report |
| title_full | Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report |
| title_fullStr | Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report |
| title_full_unstemmed | Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report |
| title_short | Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report |
| title_sort | severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange a case report |
| topic | Leptospirosis Zoonotic infection Pulmonary hemorrhages Myocarditis Multiple organ failure Plasma exchange |
| url | https://doi.org/10.1186/s13256-021-03135-3 |
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