Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography
Introduction: Successfully detecting and managing Liver Fibrosis (LF) at an early phase can significantly improve the prognosis of patients in clinical practice; therefore, accurately assessing the degree of fibrosis when the disease is at an early stage is extremely important. However, the norm...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10869/29777_251117_29777_CE(RA1)_F(AP)_PF1(BT_PB_SU_AP)_PFA(PB_AP).pdf |
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| author | VEERENDRA KUMAR SHARMA ANKUR MALHOTRA TARUN KUMAR CHAUHAN |
| author_facet | VEERENDRA KUMAR SHARMA ANKUR MALHOTRA TARUN KUMAR CHAUHAN |
| author_sort | VEERENDRA KUMAR SHARMA |
| collection | DOAJ |
| description | Introduction: Successfully detecting and managing Liver
Fibrosis (LF) at an early phase can significantly improve the
prognosis of patients in clinical practice; therefore, accurately
assessing the degree of fibrosis when the disease is at an early
stage is extremely important. However, the normal range of
Liver Stiffness (LS) on Point Shear Wave Elastography (PSWE)
is not well established.
Aim: The present study aimed to quantitatively evaluate and
compare sonoelastographic values of liver stiffness in healthy
individuals without any clinical complaints.
Materials and Methods: A prospective cross-sectional study
was done from November 2014 to January 2017 in a tertiary
care hospital in Uttarakhand region. The mean kilopascal value
of 10 consecutive measurements were used as representative
value for each healthy individual. The effects of potential
confounding factors (age, gender, hepatic steatosis, and BMI)
on liver elasticity were evaluated. Results were evaluated using
SPSS© for windows™ Vs 23 (IBM™ Corp NY) and Microsoft
excel™ 2007(Microsoft® Inc USA). Student’s t-test was used to
check the significance of difference between two parameters.
ANOVA followed by Tukey’s HSD test was used to test the
significance of difference between more than two parameters
in parametric data.
Results: A total of 207 healthy individuals out of which 59 had
fatty liver (incidentally detected) formed a part of this study.
Reference range of liver stiffness in total study population was
4.48±0.78 kPa. Liver stiffness in males was 4.56±0.76 kPa
and in females was 4.32±0.80 kPa. Reference range of liver
stiffness for fatty liver was 4.59±0.84 kPa and for healthy liver
was 4.47±0.75.
Conclusion: Normal reference range of liver stiffness in healthy
individuals in Uttarakhand region was 4.48±0.78 kPa. Of all the
confounding factors only males have significant higher liver
elasticity as compared to females. Other confounding factors
have no significant effect on liver elasticity. |
| first_indexed | 2024-12-21T00:24:48Z |
| format | Article |
| id | doaj.art-e16ed5e961e143a29746c30d1e19dcf5 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T00:24:48Z |
| publishDate | 2017-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-e16ed5e961e143a29746c30d1e19dcf52022-12-21T19:22:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-11-011111TC13TC1610.7860/JCDR/2017/29777.10869Evaluation of Liver Stiffness in Healthy Individuals by SonoelastographyVEERENDRA KUMAR SHARMA0ANKUR MALHOTRA1TARUN KUMAR CHAUHAN2Assistant Professor, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India.Assistant Professor, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India.Postgraduate Student, Department of Radiology, Shri Mahant Indiresh Hospital, Dehradun, Uttarakhand, India.Introduction: Successfully detecting and managing Liver Fibrosis (LF) at an early phase can significantly improve the prognosis of patients in clinical practice; therefore, accurately assessing the degree of fibrosis when the disease is at an early stage is extremely important. However, the normal range of Liver Stiffness (LS) on Point Shear Wave Elastography (PSWE) is not well established. Aim: The present study aimed to quantitatively evaluate and compare sonoelastographic values of liver stiffness in healthy individuals without any clinical complaints. Materials and Methods: A prospective cross-sectional study was done from November 2014 to January 2017 in a tertiary care hospital in Uttarakhand region. The mean kilopascal value of 10 consecutive measurements were used as representative value for each healthy individual. The effects of potential confounding factors (age, gender, hepatic steatosis, and BMI) on liver elasticity were evaluated. Results were evaluated using SPSS© for windows™ Vs 23 (IBM™ Corp NY) and Microsoft excel™ 2007(Microsoft® Inc USA). Student’s t-test was used to check the significance of difference between two parameters. ANOVA followed by Tukey’s HSD test was used to test the significance of difference between more than two parameters in parametric data. Results: A total of 207 healthy individuals out of which 59 had fatty liver (incidentally detected) formed a part of this study. Reference range of liver stiffness in total study population was 4.48±0.78 kPa. Liver stiffness in males was 4.56±0.76 kPa and in females was 4.32±0.80 kPa. Reference range of liver stiffness for fatty liver was 4.59±0.84 kPa and for healthy liver was 4.47±0.75. Conclusion: Normal reference range of liver stiffness in healthy individuals in Uttarakhand region was 4.48±0.78 kPa. Of all the confounding factors only males have significant higher liver elasticity as compared to females. Other confounding factors have no significant effect on liver elasticity.https://jcdr.net/articles/PDF/10869/29777_251117_29777_CE(RA1)_F(AP)_PF1(BT_PB_SU_AP)_PFA(PB_AP).pdffatty liverfibrosisliversonoelastography |
| spellingShingle | VEERENDRA KUMAR SHARMA ANKUR MALHOTRA TARUN KUMAR CHAUHAN Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography Journal of Clinical and Diagnostic Research fatty liver fibrosis liver sonoelastography |
| title | Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography |
| title_full | Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography |
| title_fullStr | Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography |
| title_full_unstemmed | Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography |
| title_short | Evaluation of Liver Stiffness in Healthy Individuals by Sonoelastography |
| title_sort | evaluation of liver stiffness in healthy individuals by sonoelastography |
| topic | fatty liver fibrosis liver sonoelastography |
| url | https://jcdr.net/articles/PDF/10869/29777_251117_29777_CE(RA1)_F(AP)_PF1(BT_PB_SU_AP)_PFA(PB_AP).pdf |
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