IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.
Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 we...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205109/pdf/?tool=EBI |
| _version_ | 1818338209568915456 |
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| author | Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae |
| author_facet | Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae |
| author_sort | Wakako Nakanishi |
| collection | DOAJ |
| description | Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans. |
| first_indexed | 2024-12-13T15:07:28Z |
| format | Article |
| id | doaj.art-e170c11784454e06b17cb6087b4db2cd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:07:28Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e170c11784454e06b17cb6087b4db2cd2022-12-21T23:40:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7809910.1371/journal.pone.0078099IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis.Wakako NakanishiSachiko YamaguchiAkira MatsudaMaho SuzukawaAkiko ShibuiAya NambuKenji KondoHajime SutoHirohisa SaitoKenji MatsumotoTatuya YamasobaSusumu NakaeBoth interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205109/pdf/?tool=EBI |
| spellingShingle | Wakako Nakanishi Sachiko Yamaguchi Akira Matsuda Maho Suzukawa Akiko Shibui Aya Nambu Kenji Kondo Hajime Suto Hirohisa Saito Kenji Matsumoto Tatuya Yamasoba Susumu Nakae IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS ONE |
| title | IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_full | IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_fullStr | IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_full_unstemmed | IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_short | IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. |
| title_sort | il 33 but not il 25 is crucial for the development of house dust mite antigen induced allergic rhinitis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205109/pdf/?tool=EBI |
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