A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis

A Specific Reduction in Aβ1−42 vs. a Universal Loss of Aβ Peptides in CSF Differentiates Alzheimer's Disease From Meningitis and Multiple Sclerosis

A reduced concentration of Aβ1−42 in CSF is one of the established biomarkers of Alzheimer's disease. Reduced CSF concentrations of Aβ1−42 have also been shown in multiple sclerosis, viral encephalitis and bacterial meningitis. As neuroinflammation is one of the neuropathological hallmarks of A...

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Bibliographic Details
Main Authors: Philipp Spitzer, Roland Lang, Timo J. Oberstein, Piotr Lewczuk, Natalia Ermann, Hagen B. Huttner, Ilias Masouris, Johannes Kornhuber, Uwe Ködel, Juan M. Maler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
meningitis
amyloid
Alzheimer's disease
multiple sclerosis
biomarker
dementia
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00152/full

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