Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/3/595 |
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| author | Ahmed Kandeil Yassmin Moatasim Ahmed El Taweel Mohamed El Sayes Adam Rubrum Trushar Jeevan Pamela P. McKenzie Richard J. Webby Mohamed A. Ali Ghazi Kayali Rabeh El-Shesheny |
| author_facet | Ahmed Kandeil Yassmin Moatasim Ahmed El Taweel Mohamed El Sayes Adam Rubrum Trushar Jeevan Pamela P. McKenzie Richard J. Webby Mohamed A. Ali Ghazi Kayali Rabeh El-Shesheny |
| author_sort | Ahmed Kandeil |
| collection | DOAJ |
| description | In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least six genotypes of Highly Pathogenic Avian Influenza (HPAI) H5N8 viruses with evidence of partial or complete annual replacement of dominant strains. Although all Egyptian H5N8 viruses had clade 2.3.4.4b hemagglutinin (HA) genes, the remaining viral gene segments were from multiple geographic origins, indicating that the H5N8 isolates resulted from multiple introductions. Mutations in the viral proteins associated with pathogenicity and antiviral drug resistance were detected. Some mutations in the HA resulted in antigenic drift. Heterogeneity in circulating H5N8 HPAI threatens poultry production and public health. |
| first_indexed | 2024-03-09T13:15:57Z |
| format | Article |
| id | doaj.art-e172a6eb4c704496bf5ead231269306d |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T13:15:57Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-e172a6eb4c704496bf5ead231269306d2023-11-30T21:36:37ZengMDPI AGMicroorganisms2076-26072022-03-0110359510.3390/microorganisms10030595Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021Ahmed Kandeil0Yassmin Moatasim1Ahmed El Taweel2Mohamed El Sayes3Adam Rubrum4Trushar Jeevan5Pamela P. McKenzie6Richard J. Webby7Mohamed A. Ali8Ghazi Kayali9Rabeh El-Shesheny10Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptDepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USACenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptHuman Link, Dubai 971, United Arab EmiratesCenter of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, EgyptIn Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least six genotypes of Highly Pathogenic Avian Influenza (HPAI) H5N8 viruses with evidence of partial or complete annual replacement of dominant strains. Although all Egyptian H5N8 viruses had clade 2.3.4.4b hemagglutinin (HA) genes, the remaining viral gene segments were from multiple geographic origins, indicating that the H5N8 isolates resulted from multiple introductions. Mutations in the viral proteins associated with pathogenicity and antiviral drug resistance were detected. Some mutations in the HA resulted in antigenic drift. Heterogeneity in circulating H5N8 HPAI threatens poultry production and public health.https://www.mdpi.com/2076-2607/10/3/595Egypthighly pathogenic avian influenzaH5N8phylogenetic analysisreassortment |
| spellingShingle | Ahmed Kandeil Yassmin Moatasim Ahmed El Taweel Mohamed El Sayes Adam Rubrum Trushar Jeevan Pamela P. McKenzie Richard J. Webby Mohamed A. Ali Ghazi Kayali Rabeh El-Shesheny Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 Microorganisms Egypt highly pathogenic avian influenza H5N8 phylogenetic analysis reassortment |
| title | Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 |
| title_full | Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 |
| title_fullStr | Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 |
| title_full_unstemmed | Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 |
| title_short | Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021 |
| title_sort | genetic and antigenic characteristics of highly pathogenic avian influenza a h5n8 viruses circulating in domestic poultry in egypt 2017 2021 |
| topic | Egypt highly pathogenic avian influenza H5N8 phylogenetic analysis reassortment |
| url | https://www.mdpi.com/2076-2607/10/3/595 |
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