Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China
ABSTRACTIn the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continu...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1754137 |
| _version_ | 1797265905808310272 |
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| author | Heng Wang Wei-min Xu Kuang-ji Zhu Su-juan Zhu Hong-fang Zhang Jia Wang Yang Yang Feng-yao Shao Neng-ming Jiang Zhen-yang Tao Hang-yi Jin Yi Tang Liang-liang Huo Fang Dong Zhen-jun Li Hua Ding Zhi-guo Liu |
| author_facet | Heng Wang Wei-min Xu Kuang-ji Zhu Su-juan Zhu Hong-fang Zhang Jia Wang Yang Yang Feng-yao Shao Neng-ming Jiang Zhen-yang Tao Hang-yi Jin Yi Tang Liang-liang Huo Fang Dong Zhen-jun Li Hua Ding Zhi-guo Liu |
| author_sort | Heng Wang |
| collection | DOAJ |
| description | ABSTRACTIn the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 Brucella strains containing 4 biotypes were obtained, including Brucella melitensis bv.1 (n = 8) and bv.3 (n = 106), Brucella abortus bv.3 (n = 3) and bv.7 (n = 1). Twenty-one shared MLVA-16 genotypes, each composed of 2 to 19 strains obtained from different hosts, suggest the occurrence of a brucellosis outbreak epidemic with multiple source points and laboratory infection events. Moreover, 30 shared MLVA-16 genotypes were observed among 59.6% (68/114) B. melitensis isolates from Zhejiang and strains from other 21 different provinces, especially northern provinces, China. The analysis highlighted the imported nature of the strains from all over the northern provinces with a dominant part from the developed areas of animal husbandry. These data revealed a potential transmission pattern of brucellosis in this region, due to introduced infected sheep leading to a brucellosis outbreak epidemic, and eventually causing multiple laboratory infection events. It is urgent to strengthen the inspection and quarantine of the introduced animals. |
| first_indexed | 2024-03-07T17:24:35Z |
| format | Article |
| id | doaj.art-e17329dbfaf04a39a27dfdb48325fa02 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:52:14Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-e17329dbfaf04a39a27dfdb48325fa022024-03-11T16:04:23ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019188989910.1080/22221751.2020.1754137Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, ChinaHeng Wang0Wei-min Xu1Kuang-ji Zhu2Su-juan Zhu3Hong-fang Zhang4Jia Wang5Yang Yang6Feng-yao Shao7Neng-ming Jiang8Zhen-yang Tao9Hang-yi Jin10Yi Tang11Liang-liang Huo12Fang Dong13Zhen-jun Li14Hua Ding15Zhi-guo Liu16Hangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaJinhua WuCheng District Center for Disease Control and Prevention, WuCheng, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaTongxiang Shi Center for Disease Control and Prevention, Tongxiang, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaJinhua WuCheng District Center for Disease Control and Prevention, WuCheng, People’s Republic of ChinaJinhua Jindong District Center for Disease Control and Prevention, Jindong, People’s Republic of ChinaJinhua Jindong District Center for Disease Control and Prevention, Jindong, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaHangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of ChinaABSTRACTIn the present study, a total of 7793 samples from 5 different types of hosts were collected and tested, with a seroprevalence of 2.4% (184/7793). Although the seroprevalence of human and animal brucellosis is relatively low, numbers of human brucellosis cases reported have increased continuously from 2004 to 2018. A total of 118 Brucella strains containing 4 biotypes were obtained, including Brucella melitensis bv.1 (n = 8) and bv.3 (n = 106), Brucella abortus bv.3 (n = 3) and bv.7 (n = 1). Twenty-one shared MLVA-16 genotypes, each composed of 2 to 19 strains obtained from different hosts, suggest the occurrence of a brucellosis outbreak epidemic with multiple source points and laboratory infection events. Moreover, 30 shared MLVA-16 genotypes were observed among 59.6% (68/114) B. melitensis isolates from Zhejiang and strains from other 21 different provinces, especially northern provinces, China. The analysis highlighted the imported nature of the strains from all over the northern provinces with a dominant part from the developed areas of animal husbandry. These data revealed a potential transmission pattern of brucellosis in this region, due to introduced infected sheep leading to a brucellosis outbreak epidemic, and eventually causing multiple laboratory infection events. It is urgent to strengthen the inspection and quarantine of the introduced animals.https://www.tandfonline.com/doi/10.1080/22221751.2020.1754137B. melitensisB. abortusMLVAtrace-backlaboratory infectionZhejiang province |
| spellingShingle | Heng Wang Wei-min Xu Kuang-ji Zhu Su-juan Zhu Hong-fang Zhang Jia Wang Yang Yang Feng-yao Shao Neng-ming Jiang Zhen-yang Tao Hang-yi Jin Yi Tang Liang-liang Huo Fang Dong Zhen-jun Li Hua Ding Zhi-guo Liu Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China Emerging Microbes and Infections B. melitensis B. abortus MLVA trace-back laboratory infection Zhejiang province |
| title | Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China |
| title_full | Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China |
| title_fullStr | Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China |
| title_full_unstemmed | Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China |
| title_short | Molecular investigation of infection sources and transmission chains of brucellosis in Zhejiang, China |
| title_sort | molecular investigation of infection sources and transmission chains of brucellosis in zhejiang china |
| topic | B. melitensis B. abortus MLVA trace-back laboratory infection Zhejiang province |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1754137 |
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