Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions

Three-Component Reaction of Benzylamines, Diethyl Phosphite and Triethyl Orthoformate: Dependence of the Reaction Course on the Structural Features of the Substrates and Reaction Conditions

The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions...

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Bibliographic Details
Main Authors: Patrycja Miszczyk, Ilona Turowska-Tyrk, Paweł Kafarski, Ewa Chmielewska
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
bisphosphonates
aminophosphonates
N-benzylaminomethylenebisphosphonic acid
N-benzylaminobenzylphosphonates
synthesis of C-P bond
multicomponent reactions
Online Access:http://www.mdpi.com/1420-3049/22/3/450
Description
Summary:The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.
ISSN:1420-3049

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