Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent
This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2011-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=en |
| _version_ | 1818554465527005184 |
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| author | Roberto E.P. Sica Alejandro F. De Nicola María C. González Deniselle Gabriel Rodriguez Gisella M. Gargiulo Monachelli Liliana Martinez Peralta Mariela Bettini |
| author_facet | Roberto E.P. Sica Alejandro F. De Nicola María C. González Deniselle Gabriel Rodriguez Gisella M. Gargiulo Monachelli Liliana Martinez Peralta Mariela Bettini |
| author_sort | Roberto E.P. Sica |
| collection | DOAJ |
| description | This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown environmental agent, while neuronal death may be a secondary event following the initial insult to glial cells. The article also suggests that an emergent virus or a misfolded infectious protein might be potential candidates to accomplish this task. |
| first_indexed | 2024-12-12T09:39:51Z |
| format | Article |
| id | doaj.art-e175cc2842504fe5ac0276c78c1cd542 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-12T09:39:51Z |
| publishDate | 2011-08-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-e175cc2842504fe5ac0276c78c1cd5422022-12-22T00:28:37ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272011-08-0169469970610.1590/S0004-282X2011000500023S0004-282X2011000500023Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agentRoberto E.P. SicaAlejandro F. De NicolaMaría C. González DeniselleGabriel RodriguezGisella M. Gargiulo MonachelliLiliana Martinez PeraltaMariela BettiniThis article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown environmental agent, while neuronal death may be a secondary event following the initial insult to glial cells. The article also suggests that an emergent virus or a misfolded infectious protein might be potential candidates to accomplish this task.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=enesclerosis lateral amiotróficaesclerosis lateral amiotrófica esporádicapatogeniaastrocito |
| spellingShingle | Roberto E.P. Sica Alejandro F. De Nicola María C. González Deniselle Gabriel Rodriguez Gisella M. Gargiulo Monachelli Liliana Martinez Peralta Mariela Bettini Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent Arquivos de Neuro-Psiquiatria esclerosis lateral amiotrófica esclerosis lateral amiotrófica esporádica patogenia astrocito |
| title | Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| title_full | Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| title_fullStr | Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| title_full_unstemmed | Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| title_short | Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| title_sort | sporadic amyotrophic lateral sclerosis new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent |
| topic | esclerosis lateral amiotrófica esclerosis lateral amiotrófica esporádica patogenia astrocito |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000500023&lng=en&tlng=en |
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