Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil
Abstract Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05086-4 |
| _version_ | 1819202287835283456 |
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| author | Emilie Mosnier Isabelle Dusfour Guillaume Lacour Raphael Saldanha Amandine Guidez Margarete S. Gomes Alice Sanna Yanouk Epelboin Johana Restrepo Damien Davy Magalie Demar Félix Djossou Maylis Douine Vanessa Ardillon Mathieu Nacher Lise Musset Emmanuel Roux |
| author_facet | Emilie Mosnier Isabelle Dusfour Guillaume Lacour Raphael Saldanha Amandine Guidez Margarete S. Gomes Alice Sanna Yanouk Epelboin Johana Restrepo Damien Davy Magalie Demar Félix Djossou Maylis Douine Vanessa Ardillon Mathieu Nacher Lise Musset Emmanuel Roux |
| author_sort | Emilie Mosnier |
| collection | DOAJ |
| description | Abstract Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems. Results On the French Guianese side of the border in Saint-Georges de l’Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n = 1104, 0.18%) were found to be Pv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases of Pv infection. Temporal distribution during the 2007–2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities. Conclusions The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations. |
| first_indexed | 2024-12-23T04:01:38Z |
| format | Article |
| id | doaj.art-e176306ca99b4b4d88bf4f8dfb5d46ae |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-23T04:01:38Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-e176306ca99b4b4d88bf4f8dfb5d46ae2022-12-21T18:00:44ZengBMCBMC Infectious Diseases1471-23342020-05-0120111410.1186/s12879-020-05086-4Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and BrazilEmilie Mosnier0Isabelle Dusfour1Guillaume Lacour2Raphael Saldanha3Amandine Guidez4Margarete S. Gomes5Alice Sanna6Yanouk Epelboin7Johana Restrepo8Damien Davy9Magalie Demar10Félix Djossou11Maylis Douine12Vanessa Ardillon13Mathieu Nacher14Lise Musset15Emmanuel Roux16Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée RosemonUnité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la GuyaneUnité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la GuyaneLIS, ICICT, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, Brazil; International Join Laboratory Sentinela, IRD, Fiocruz, University of BrasíliaUnité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la GuyaneSuperintendência de Vigilância em Saúde do Amapá (SVS-AP)Agence Régionale de la Santé, 66 rue des flamboyantsUnité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la GuyaneService d’Entomologie de la Direction Démoustication et Actions Sanitaires, collectivité Térritoriale de GuyaneLEEISA (Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens), CNRS, Université de GuyaneLaboratoire de Parasitologie et Mycologie, Centre Hospitalier Andrée RosemonUnité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée RosemonUniversité de Guyane, EA3593 Ecosystèmes Amazoniens et Pathologie TropicaleCIRE Guyane, 66 rue des flamboyantsCentre d’Investigation Clinique Antilles Guyane – Inserm 1424, Centre Hospitalier Andrée RosemonLaboratoire de parasitologie, Centre National de Référence du Paludisme, Pôle Zones Endémiques, WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Institut Pasteur de la GuyaneESPACE-DEV, IRD, Universités de Montpellier, de La Réunion, de la Guyane, des Antilles, Montpellier, France: LIS, ICICTAbstract Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems. Results On the French Guianese side of the border in Saint-Georges de l’Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak of Anopheles darlingi density in August and September. Two female An. darlingi (n = 1104, 0.18%) were found to be Pv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases of Pv infection. Temporal distribution during the 2007–2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities. Conclusions The current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations.http://link.springer.com/article/10.1186/s12879-020-05086-4Plasmodium vivaxAnopheles darlingiFrench GuianaBrazilTransnationalOutbreak investigation |
| spellingShingle | Emilie Mosnier Isabelle Dusfour Guillaume Lacour Raphael Saldanha Amandine Guidez Margarete S. Gomes Alice Sanna Yanouk Epelboin Johana Restrepo Damien Davy Magalie Demar Félix Djossou Maylis Douine Vanessa Ardillon Mathieu Nacher Lise Musset Emmanuel Roux Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil BMC Infectious Diseases Plasmodium vivax Anopheles darlingi French Guiana Brazil Transnational Outbreak investigation |
| title | Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil |
| title_full | Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil |
| title_fullStr | Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil |
| title_full_unstemmed | Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil |
| title_short | Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil |
| title_sort | resurgence risk for malaria and the characterization of a recent outbreak in an amazonian border area between french guiana and brazil |
| topic | Plasmodium vivax Anopheles darlingi French Guiana Brazil Transnational Outbreak investigation |
| url | http://link.springer.com/article/10.1186/s12879-020-05086-4 |
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