| Summary: | Despite being a relatively rare pathology, neonatal lupus erythematosus can affect the body in different ways, with a risk of death, especially in the first three months of life. Studies show that in asymptomatic pregnant women or those with autoimmune disease with positive Ro/SSA, La/SSB and RNP antibodies, the transplacental passage of these antibodies after the 16th week can cause damage to target organs. Most of the lesions, especially the skin, gradually decrease and disappear, as these antibodies are eliminated from the circulation; however, in the heart, fibrosis can induce permanent damage. Despite the knowledge of the importance of these antibodies in the pathophysiology of neonatal lupus, it is necessary to better understand the genetic and environmental factors of the disease. Lesions caused by lupus are generally benign and self-limiting. However, atrioventricular block is an exception, causing significant morbidity and mortality. This paper seeks to focus on the investigation of neonatal lupus erythematosus, on understanding the systemic manifestations of the disease, in order to understand the involvement of fetal organs.
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