Mechanotransduction: Tuning Stem Cells Fate
It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-4983/2/2/67/ |
| _version_ | 1811302336965902336 |
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| author | Aldo Orlacchio Sabata Martino Josè Maria Kenny Ilaria Armentano Roberto Tiribuzi Francesco D’Angelo |
| author_facet | Aldo Orlacchio Sabata Martino Josè Maria Kenny Ilaria Armentano Roberto Tiribuzi Francesco D’Angelo |
| author_sort | Aldo Orlacchio |
| collection | DOAJ |
| description | It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction. |
| first_indexed | 2024-04-13T07:26:13Z |
| format | Article |
| id | doaj.art-e176ae339dfc487b99fac0b26494aa04 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-13T07:26:13Z |
| publishDate | 2011-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-e176ae339dfc487b99fac0b26494aa042022-12-22T02:56:28ZengMDPI AGJournal of Functional Biomaterials2079-49832011-06-0122678710.3390/jfb2020067Mechanotransduction: Tuning Stem Cells FateAldo OrlacchioSabata MartinoJosè Maria KennyIlaria ArmentanoRoberto TiribuziFrancesco D’AngeloIt is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.http://www.mdpi.com/2079-4983/2/2/67/ESCsASCsiPSmechanotransductionregenerative medicinetissue engineering |
| spellingShingle | Aldo Orlacchio Sabata Martino Josè Maria Kenny Ilaria Armentano Roberto Tiribuzi Francesco D’Angelo Mechanotransduction: Tuning Stem Cells Fate Journal of Functional Biomaterials ESCs ASCs iPS mechanotransduction regenerative medicine tissue engineering |
| title | Mechanotransduction: Tuning Stem Cells Fate |
| title_full | Mechanotransduction: Tuning Stem Cells Fate |
| title_fullStr | Mechanotransduction: Tuning Stem Cells Fate |
| title_full_unstemmed | Mechanotransduction: Tuning Stem Cells Fate |
| title_short | Mechanotransduction: Tuning Stem Cells Fate |
| title_sort | mechanotransduction tuning stem cells fate |
| topic | ESCs ASCs iPS mechanotransduction regenerative medicine tissue engineering |
| url | http://www.mdpi.com/2079-4983/2/2/67/ |
| work_keys_str_mv | AT aldoorlacchio mechanotransductiontuningstemcellsfate AT sabatamartino mechanotransductiontuningstemcellsfate AT josemariakenny mechanotransductiontuningstemcellsfate AT ilariaarmentano mechanotransductiontuningstemcellsfate AT robertotiribuzi mechanotransductiontuningstemcellsfate AT francescodangelo mechanotransductiontuningstemcellsfate |