Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report
Polio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosi...
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MDPI AG
2024-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/13/3/198 |
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| author | Mathy Matungala-Pafubel Junior Bulabula-Penge Meris Matondo-Kuamfumu Samy Esala François Edidi-Atani Elisabeth Pukuta-Simbu Paul Tshiminyi-Munkamba Yannick Tutu Tshia N’kasar Trésor Katanga Etienne Ndomba-Mukanya Delphine Mbonga-Mande Lionel Baketana-Kinzonzi Eddy Kinganda-Lusamaki Daniel Mukadi-Bamuleka Fabrice Mambu-Mbika Placide Mbala-Kingebeni Edith Nkwembe-Ngabana Antoine Nkuba-Ndaye Daniel Okitundu-Luwa Steve Ahuka-Mundeke |
| author_facet | Mathy Matungala-Pafubel Junior Bulabula-Penge Meris Matondo-Kuamfumu Samy Esala François Edidi-Atani Elisabeth Pukuta-Simbu Paul Tshiminyi-Munkamba Yannick Tutu Tshia N’kasar Trésor Katanga Etienne Ndomba-Mukanya Delphine Mbonga-Mande Lionel Baketana-Kinzonzi Eddy Kinganda-Lusamaki Daniel Mukadi-Bamuleka Fabrice Mambu-Mbika Placide Mbala-Kingebeni Edith Nkwembe-Ngabana Antoine Nkuba-Ndaye Daniel Okitundu-Luwa Steve Ahuka-Mundeke |
| author_sort | Mathy Matungala-Pafubel |
| collection | DOAJ |
| description | Polio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosis, which is necessary for better management and response. From September 2022 to April 2023, we investigated acute flaccid paralysis (AFP) cases in Kinshasa following an alert from the Provincial Division of Health. All suspected cases and their close contacts were investigated and sampled. Among the 57 sampled patients, 21 (36.8%) were suspects, and 36 (63.2%) were contacts. We performed several etiological tests available in the laboratory, targeting viruses, including Poliovirus, Influenza virus, SARS-CoV-2, Enterovirus, and arboviruses. No virus material was detected, but the serological test (ELISA) detected antibodies against Chikungunya Virus, i.e., 47.4% (27/57) for IgM and 22.8% (13/57) for IgG. Among suspected cases, we detected 33.3% (7/21) with anti-Chikungunya IgM and 14.3% (3/21) of anti-Chikungunya IgG. These results highlight the importance of enhancing the epidemiological surveillance of Chikungunya. |
| first_indexed | 2024-04-24T17:56:37Z |
| format | Article |
| id | doaj.art-e176b3429d914529bf15327fc239c4c9 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-24T17:56:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e176b3429d914529bf15327fc239c4c92024-03-27T13:58:49ZengMDPI AGPathogens2076-08172024-02-0113319810.3390/pathogens13030198Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey ReportMathy Matungala-Pafubel0Junior Bulabula-Penge1Meris Matondo-Kuamfumu2Samy Esala3François Edidi-Atani4Elisabeth Pukuta-Simbu5Paul Tshiminyi-Munkamba6Yannick Tutu Tshia N’kasar7Trésor Katanga8Etienne Ndomba-Mukanya9Delphine Mbonga-Mande10Lionel Baketana-Kinzonzi11Eddy Kinganda-Lusamaki12Daniel Mukadi-Bamuleka13Fabrice Mambu-Mbika14Placide Mbala-Kingebeni15Edith Nkwembe-Ngabana16Antoine Nkuba-Ndaye17Daniel Okitundu-Luwa18Steve Ahuka-Mundeke19Département de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDivision Provinciale de la Santé de Kinshasa, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDirection de Surveillance Epidémiologique de Kinshasa, Ministère de Santé, Hygiène et Prévention, Kinshasa 01204, Democratic Republic of the CongoDivision Provinciale de la Santé de Kinshasa, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoCentre Neuro-Psycho-Pathologie, Kinshasa H8V3+CJ3, Democratic Republic of the CongoDépartement de Virologie, Institut National de Recherche Biomédicale, Kinshasa 01204, Democratic Republic of the CongoPolio-associated paralysis is one of the diseases under national surveillance in the Democratic Republic of the Congo (DRC). Although it has become relatively rare due to control measures, non-polio paralysis cases are still reported and constitute a real problem, especially for etiological diagnosis, which is necessary for better management and response. From September 2022 to April 2023, we investigated acute flaccid paralysis (AFP) cases in Kinshasa following an alert from the Provincial Division of Health. All suspected cases and their close contacts were investigated and sampled. Among the 57 sampled patients, 21 (36.8%) were suspects, and 36 (63.2%) were contacts. We performed several etiological tests available in the laboratory, targeting viruses, including Poliovirus, Influenza virus, SARS-CoV-2, Enterovirus, and arboviruses. No virus material was detected, but the serological test (ELISA) detected antibodies against Chikungunya Virus, i.e., 47.4% (27/57) for IgM and 22.8% (13/57) for IgG. Among suspected cases, we detected 33.3% (7/21) with anti-Chikungunya IgM and 14.3% (3/21) of anti-Chikungunya IgG. These results highlight the importance of enhancing the epidemiological surveillance of Chikungunya.https://www.mdpi.com/2076-0817/13/3/198paralysischikungunyaKinshasa |
| spellingShingle | Mathy Matungala-Pafubel Junior Bulabula-Penge Meris Matondo-Kuamfumu Samy Esala François Edidi-Atani Elisabeth Pukuta-Simbu Paul Tshiminyi-Munkamba Yannick Tutu Tshia N’kasar Trésor Katanga Etienne Ndomba-Mukanya Delphine Mbonga-Mande Lionel Baketana-Kinzonzi Eddy Kinganda-Lusamaki Daniel Mukadi-Bamuleka Fabrice Mambu-Mbika Placide Mbala-Kingebeni Edith Nkwembe-Ngabana Antoine Nkuba-Ndaye Daniel Okitundu-Luwa Steve Ahuka-Mundeke Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report Pathogens paralysis chikungunya Kinshasa |
| title | Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report |
| title_full | Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report |
| title_fullStr | Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report |
| title_full_unstemmed | Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report |
| title_short | Lower Limb Paralysis Associated with Chikungunya in Kinshasa, the Democratic Republic of the Congo: Survey Report |
| title_sort | lower limb paralysis associated with chikungunya in kinshasa the democratic republic of the congo survey report |
| topic | paralysis chikungunya Kinshasa |
| url | https://www.mdpi.com/2076-0817/13/3/198 |
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