Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories
Introduction:The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. Materials and Methods:1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Geneti...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2010-03-01
|
| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/237 |
| _version_ | 1797726538452434944 |
|---|---|
| author | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar |
| author_facet | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar |
| author_sort | Alireza Moafi |
| collection | DOAJ |
| description | Introduction:The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran.
Materials and Methods:1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated.
Results: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with 78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, race and familial relationships.
Conclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately. |
| first_indexed | 2024-03-12T10:47:04Z |
| format | Article |
| id | doaj.art-e177ddf8c3e74e28a0239de00c909e81 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T10:47:04Z |
| publishDate | 2010-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-e177ddf8c3e74e28a0239de00c909e812023-09-02T07:31:58ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072010-03-0141Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic LaboratoriesAlireza Moafi0Sadeg Valian1Zahra Nikyar2Mehrdad Zeinalian3Maryam Momenzadeh4Soheila Rahgozar5Department of Pediatric Hematology-Oncology, Isfahan University of Medical Sciences, Isfahan, IranDivision of Genetics, Department of Biology, University of Isfahan, Isfahan, IranDepartment of Pediatric Hematology-Oncology, Isfahan University of Medical Sciences, Isfahan, IranThe Office of Health Services, Isfahan University of Medical Sciences, Isfahan, IranThe Office of Health Services, Isfahan University of Medical Sciences, Isfahan, IranDivision of Molecular and Cell Biology, Department of Biology, University of Isfahan, Isfahan, IranIntroduction:The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. Materials and Methods:1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. Results: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with 78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, race and familial relationships. Conclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/237Minor β-ThalassemiaScreeningMCHMCVThalassemia Preventing Program |
| spellingShingle | Alireza Moafi Sadeg Valian Zahra Nikyar Mehrdad Zeinalian Maryam Momenzadeh Soheila Rahgozar Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories International Journal of Hematology-Oncology and Stem Cell Research Minor β-Thalassemia Screening MCH MCV Thalassemia Preventing Program |
| title | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_full | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_fullStr | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_full_unstemmed | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_short | Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
| title_sort | prevalence of minor β thalassemia based on rbc indices among final suspected individuals in premarital screening program referred to genetic laboratories |
| topic | Minor β-Thalassemia Screening MCH MCV Thalassemia Preventing Program |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/237 |
| work_keys_str_mv | AT alirezamoafi prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories AT sadegvalian prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories AT zahranikyar prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories AT mehrdadzeinalian prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories AT maryammomenzadeh prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories AT soheilarahgozar prevalenceofminorbthalassemiabasedonrbcindicesamongfinalsuspectedindividualsinpremaritalscreeningprogramreferredtogeneticlaboratories |