A novel action of lacosamide on GABAA currents sets the ground for a synergic interaction with levetiracetam in treatment of epilepsy

A novel action of lacosamide on GABAA currents sets the ground for a synergic interaction with levetiracetam in treatment of epilepsy

Epilepsy is one of the most common chronic neurological diseases, and its pharmacological treatment holds great importance for both physicians and national authorities, especially considering the high proportion of drug-resistant patients (about 30%). Lacosamide (LCM) is an effective and well-tolera...

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Bibliographic Details
Main Authors: Gabriele Ruffolo, Carlo Di Bonaventura, Pierangelo Cifelli, Cristina Roseti, Jinane Fattouch, Alessandra Morano, Cristina Limatola, Eleonora Aronica, Eleonora Palma, Anna Teresa Giallonardo
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
GABAA receptor
Drug-resistance
Lacosamide
Levetiracetam
Xenopus oocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300949

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