Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review
BackgroundOsteosarcopenia(OS) is a significant health concern resulting from the ageing process. Currently, as the population grows older, the prevalence of OS, a disease that entails the synchronous degeneration of muscles and bones, is mounting. This poses a serious threat to the health of the eld...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1228937/full |
| _version_ | 1797647651052716032 |
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| author | Weiwei Shixuan Wang Decai Hou Libin Zhan |
| author_facet | Weiwei Shixuan Wang Decai Hou Libin Zhan |
| author_sort | Weiwei |
| collection | DOAJ |
| description | BackgroundOsteosarcopenia(OS) is a significant health concern resulting from the ageing process. Currently, as the population grows older, the prevalence of OS, a disease that entails the synchronous degeneration of muscles and bones, is mounting. This poses a serious threat to the health of the elderly while placing an enormous burden on social care. In order to comprehend the pathological mechanism of OS and develop clinical drugs, it is pertinent to construct an efficient animal model of OS. To investigate the modeling techniques of diverse experimental models of OS and elucidate their respective benefits and drawbacks, with the purpose of furnishing a theoretical foundation to advance experimental research on OS.MethodsWe searched PubMed, Embase database, China Knowledge Network, Wanfang data platform and Vipshop journal platform databases from 2000 through to September 1, 2023. We included animal studies on sarcopenia or osteoporosis or osteosarcopenia or sarcopenia-osteoporosis, modeling methods for osteosarcopenia. Two independently screened study abstracts and full reports and complete data extraction.ResultsEventually, Of 112, 106 citations screened. 4938 underwent full-text review and 38 met the inclusion criteria. we reviewed and analyzed the literature and categorized the animal models of OS into the following five categories: Aging OS models; Hormonal deficiency model of OS;Chemical injection to induce OS;Disuse OS models and Genetic engineering OS models.ConclusionThis review outlines animal modeling approaches for OS, providing a comprehensive summary of their advantages and disadvantages. The different models were evaluated and selected based on their respective strengths and weaknesses to enable higher quality research outcomes in various research directions. The most widely used and established approach is considered to be the ageing and chemical injection OS model, which has the advantages of excellent reproducibility and low cost.The translational potential of this articleTo gain a profound comprehension of the pathological mechanism of OS and to devise efficacious clinical treatments, it is imperative to establish a viable laboratory animal model of OS. This article surveys various modeling techniques assessing their benefits, drawbacks and areas of applicability while predominantly employing mice as the primary model animal. Additionally, the evaluation indicators of OS models are briefly described. |
| first_indexed | 2024-03-11T15:20:34Z |
| format | Article |
| id | doaj.art-e17a45dcd7ca40838573dd6b1ddd413e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T15:20:34Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e17a45dcd7ca40838573dd6b1ddd413e2023-10-28T21:35:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12289371228937Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review Weiwei0Shixuan Wang1Decai Hou2Libin Zhan3The Second Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaThe Second Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaAffiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaLiaoning University of Traditional Chinese Medicine, Experimental Platform, Shenyang, ChinaBackgroundOsteosarcopenia(OS) is a significant health concern resulting from the ageing process. Currently, as the population grows older, the prevalence of OS, a disease that entails the synchronous degeneration of muscles and bones, is mounting. This poses a serious threat to the health of the elderly while placing an enormous burden on social care. In order to comprehend the pathological mechanism of OS and develop clinical drugs, it is pertinent to construct an efficient animal model of OS. To investigate the modeling techniques of diverse experimental models of OS and elucidate their respective benefits and drawbacks, with the purpose of furnishing a theoretical foundation to advance experimental research on OS.MethodsWe searched PubMed, Embase database, China Knowledge Network, Wanfang data platform and Vipshop journal platform databases from 2000 through to September 1, 2023. We included animal studies on sarcopenia or osteoporosis or osteosarcopenia or sarcopenia-osteoporosis, modeling methods for osteosarcopenia. Two independently screened study abstracts and full reports and complete data extraction.ResultsEventually, Of 112, 106 citations screened. 4938 underwent full-text review and 38 met the inclusion criteria. we reviewed and analyzed the literature and categorized the animal models of OS into the following five categories: Aging OS models; Hormonal deficiency model of OS;Chemical injection to induce OS;Disuse OS models and Genetic engineering OS models.ConclusionThis review outlines animal modeling approaches for OS, providing a comprehensive summary of their advantages and disadvantages. The different models were evaluated and selected based on their respective strengths and weaknesses to enable higher quality research outcomes in various research directions. The most widely used and established approach is considered to be the ageing and chemical injection OS model, which has the advantages of excellent reproducibility and low cost.The translational potential of this articleTo gain a profound comprehension of the pathological mechanism of OS and to devise efficacious clinical treatments, it is imperative to establish a viable laboratory animal model of OS. This article surveys various modeling techniques assessing their benefits, drawbacks and areas of applicability while predominantly employing mice as the primary model animal. Additionally, the evaluation indicators of OS models are briefly described.https://www.frontiersin.org/articles/10.3389/fendo.2023.1228937/fullosteosarcopeniaanimal modelsagingreviewadvantages and disadvantages |
| spellingShingle | Weiwei Shixuan Wang Decai Hou Libin Zhan Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review Frontiers in Endocrinology osteosarcopenia animal models aging review advantages and disadvantages |
| title | Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review |
| title_full | Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review |
| title_fullStr | Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review |
| title_full_unstemmed | Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review |
| title_short | Methods and research progress in the construction of animal models of osteosarcopenia: a scoping review |
| title_sort | methods and research progress in the construction of animal models of osteosarcopenia a scoping review |
| topic | osteosarcopenia animal models aging review advantages and disadvantages |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1228937/full |
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