Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology

The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining surgical small rodent models of OA on both joint path...

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Bibliographic Details
Main Authors: Peter R. W. Gowler, Paul I. Mapp, James J. Burston, Mohsen Shahtaheri, David A. Walsh, Victoria Chapman, Simon Beggs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523978/?tool=EBI