Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6
Different subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactory bulb depends on the existence of defined microdo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/58215 |
| _version_ | 1811180573527375872 |
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| author | Nathalie Coré Andrea Erni Hanne M Hoffmann Pamela L Mellon Andrew J Saurin Christophe Beclin Harold Cremer |
| author_facet | Nathalie Coré Andrea Erni Hanne M Hoffmann Pamela L Mellon Andrew J Saurin Christophe Beclin Harold Cremer |
| author_sort | Nathalie Coré |
| collection | DOAJ |
| description | Different subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactory bulb depends on the existence of defined microdomains of pre-determined neural stem cells along the ventricle walls. The molecular mechanisms underlying positional identity of these neural stem cells are poorly understood. Here, we show that the transcription factor Vax1 controls the production of two specific neuronal subtypes. First, it is directly necessary to generate Calbindin expressing interneurons from ventro-lateral progenitors. Second, it represses the generation of dopaminergic neurons by dorsolateral progenitors through inhibition of Pax6 expression. We present data indicating that this repression occurs, at least in part, via activation of microRNA miR-7. |
| first_indexed | 2024-04-11T09:04:22Z |
| format | Article |
| id | doaj.art-e17c0541d63c4c298da3b578275d2f26 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:22Z |
| publishDate | 2020-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-e17c0541d63c4c298da3b578275d2f262022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2020-08-01910.7554/eLife.58215Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6Nathalie Coré0https://orcid.org/0000-0003-3865-4539Andrea Erni1Hanne M Hoffmann2Pamela L Mellon3Andrew J Saurin4Christophe Beclin5Harold Cremer6https://orcid.org/0000-0002-8673-5176Aix Marseille Univ, CNRS, IBDM, Campus de Luminy, Marseille, FranceAix Marseille Univ, CNRS, IBDM, Campus de Luminy, Marseille, FranceDepartment of Obstetrics, Gynecology, and Reproductive Sciences and the Center for Reproductive Science and Medicine, University of California, San Diego, San Diego, United StatesDepartment of Obstetrics, Gynecology, and Reproductive Sciences and the Center for Reproductive Science and Medicine, University of California, San Diego, San Diego, United StatesAix Marseille Univ, CNRS, IBDM, Campus de Luminy, Marseille, FranceAix Marseille Univ, CNRS, IBDM, Campus de Luminy, Marseille, FranceAix Marseille Univ, CNRS, IBDM, Campus de Luminy, Marseille, FranceDifferent subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactory bulb depends on the existence of defined microdomains of pre-determined neural stem cells along the ventricle walls. The molecular mechanisms underlying positional identity of these neural stem cells are poorly understood. Here, we show that the transcription factor Vax1 controls the production of two specific neuronal subtypes. First, it is directly necessary to generate Calbindin expressing interneurons from ventro-lateral progenitors. Second, it represses the generation of dopaminergic neurons by dorsolateral progenitors through inhibition of Pax6 expression. We present data indicating that this repression occurs, at least in part, via activation of microRNA miR-7.https://elifesciences.org/articles/58215postnatal neurogenesisregulatory interactionsolfactory bulb interneuronsneural stem cellstranscription factorsmiRNA |
| spellingShingle | Nathalie Coré Andrea Erni Hanne M Hoffmann Pamela L Mellon Andrew J Saurin Christophe Beclin Harold Cremer Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 eLife postnatal neurogenesis regulatory interactions olfactory bulb interneurons neural stem cells transcription factors miRNA |
| title | Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
| title_full | Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
| title_fullStr | Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
| title_full_unstemmed | Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
| title_short | Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6 |
| title_sort | stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between vax1 and pax6 |
| topic | postnatal neurogenesis regulatory interactions olfactory bulb interneurons neural stem cells transcription factors miRNA |
| url | https://elifesciences.org/articles/58215 |
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